EPIDEMIOLOGY Population susceptibilityBe susceptible to all the people withoutinfectionThe age of peak incidence:1 5-15yearsold85% of infections occurred inchildren below15 years of ageIncidenceofbabyunder6monthsislowerBoth clinical and inapparent infectionsprovide lifelong immunity. Reinfection isextremely rare
□ Population susceptibility □ B e susceptible to all the people without infection □ The age of peak incidence: □ 5-15 years old □ 85% of infections occurred in children below 15 years of age □ Incidence of baby under 6 m o n ths is lower □ Both clinical a nd inapparent infections provide lifelong immunity. Reinfection is extremely rare. EPIDEMIOLOGY
EPIDEMIOLOGY Epidemic Seasons Late winter and early springAlso occurringinother seasonssporadically
EPIDEMIOLOGY □ Epidemic S e a s ons □ Late winter and early spring □ Also occurring in other seasons sporadically
PATHOGENESISvirusRespiratoryepitheliumRegional lymph nodesViremiaSalivary glandsCNSMultiple organs:nerve tissues, pancreas, testicle, ovary,cardiac muscle,kidneys, etc
PATHOGENESIS virus Respiratory epithelium Regional lymph nodes Viremia Salivary g l a n ds CNS Multiple organs: nerve tissues, pancreas, testicle, ovary, cardiac muscle, kidneys, etc
PATHOLOGYParotidNonsuppurative inflammationDiffuseinterstitial e demaPunctiformhemorrhageSerofibrinous exudate with infiltrationoflymphocytesandmacrophagesStensen's ducts are obstructed图The glandularand ductalepitheliumundergoesdegenerative changes with intraluminalaccumulation of lymphocytes and debris.a)Amylase levelincreasedinserumandurineb)Painwithacidfoods
PA TH O LO G Y □ Parotid □ Nonsuppurative inflammation □ Diffuse interstitial edema □ Punctiform hemorrhage □ Serofibrinous exudate with infiltrationof lymphocytes and macrophages □ Stensen's ducts are obstructed □ The glandular and ductal epithelium undergoes degenerative changes with intraluminal accumulation of lymphocytes and debris. a) Amylase level increased in serum and urine b) Pain with acid foods
CLINICALMANIFESTATIONS Incubation period: 14-25 daysClinical picturesSystemicSymptomsSialadenitis Parotitis Submaxillaritis Sublinguitis
CLINICAL MANIFESTATIONS □ Incubation period: 14-25 days □ Clinical pictures □ Systemic Symptoms □ Sialadenitis □ Parotitis □ Submaxillaritis □ Sublinguitis