DNA LoopS(5-200 kb) SAR/MAR Nuclear scaffold matrix 6
Nuclear Scaffold/Matrix DNA Loops (5-200 kb) SAR/MAR 6
The nucleosome 146 bp dna 2XH3. H4H2A. H2B H3 H4 H2A H2B MDI not in handout
The Nucleosome 146 bp DNA 2X H3, H4, H2A, H2B H4 H2B H2A H3 Not in Handout
Blast search with s cerevisiae histone h4 Quer cerevisiae Subject: H sapiens Identities =74/82(90%),Positives 79/82(968) Query: 22 ILRDNY RRLARRGGVKRISGL SFLESVIRDSVTYTEHAKRKT 81 工 RDNIOG工TKPA工 RRLARRGGVKR工 SGLIYEE R VLK FLE+V工RD+ VTYTEHAKRKT Sbict: 21 VLRDNIOGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTY TEHAKRKT 80 Query: 82 VTSLDVVYALKRQGRTLYGEGG 103 VT++DVVYALKROGRTLYGEGG Sbjct: 81 VTAMDVVYALKRQGRTLYGEGG 102 not in handout
Identities = 74/82 (90%), Positives = 79/82 (96%) Query: 22 ILRDNIQGITKPAIRRLARRGGVKRISGLIYEEVRAVLKSFLESVIRDSVTYTEHAKRKT 81 +LRDNIQGITKPAIRRLARRGGVKRISGLIYEE R VLK FLE+VIRD+VTYTEHAKRKT Sbjct: 21 VLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKT 80 Query: 82 VTSLDVVYALKRQGRTLYGFGG 103 VT++DVVYALKRQGRTLYGFGG Sbjct: 81 VTAMDVVYALKRQGRTLYGFGG 102 Blast Search with S. cerevisiae Histone H4 Query: S. cerevisiae Subject: H. sapiens Not in Handout
Histones are low mw chromosomal proteins MW Chromosomal Proteins 200000 116,000 97,000 66.000 55,000 36000一 31.000一一 21.000一 H2 B/H3 H2A 14,000一 H4 7
MW Chromosomal Proteins 200,000 36,000 97,000 66,000 55,000 31,000 21,000 14,000 116,000 H4 H2A H2B/H3 Histones are Low MW Chromosomal Proteins 7
Domain structure of histones Core domain N L2 C .3 8
Domain Structure of Histones 1 2 3 N L1 L2 C Core Domain 8