Protein-DNA Interactions quilibria and free energies Estimate binding site occupancy Forces driving protein-DNA interactions Lambda repressor Methods to study protein-DNA interactions
Protein-DNA Interactions • Equilibria and free energies • Estimate binding site occupancy • Forces driving protein-DNA interactions • Lambda repressor • Methods to study protein-DNA interactions
Major groove Major groove H D CH DN H A N H D Minor groove Minor groove Adenine: Thymine Guanine: Cytosine
A A A A D D A A A A D M H 1
The 4 Major groove Patterns Are Distinct Maior Maior A-TA DA M G-C AADH TA MAD A C-G HDAA Minor Minor A-TA A G-C DA TAA A C-GA DA
A D A M Major A-T T-A M A D A Minor A-T T-A A A A A G-C A A D H C-G G-C C-G Major H D A A A D A A D A Minor The 4 Major Groove Patterns Are Distinct 2
Hyrdophobic groups on bases Major groove Major groove CH A H IN H H Minor groove Minor groove Adenine: Thymine Guanine: Cytosine
A A A A D D A A A A D M H 1 Hyrdophobic Groups on Bases
Helix-Turn-Helix motif 2 C 34A° N 4 2
3 Helix-Turn-Helix Motif 34 Aº