Basic Unit of Chromatin Structure: Polynucleosome Compaction ratio=6 2
Basic Unit of Chromatin Structure: Polynucleosome Compaction ratio = 6 2
Limited Micrococcal Nulcease Digestion of Chromatin Generates a 200 bp ladder 605→ 405→ 205→ 3
Limited Micrococcal Nulcease Digestion of Chromatin Generates a ~200 bp Ladder 3
Operational Definititions of Nucleosome Particles Linker DNA(variable) H HI H 200bp 165bp 146bp HI HI Chromatin Mononucleosome Chromatosome Core Particle Micrococcal Nuclease Digestion Time
H1 H1 H1 H1 H1 H1 Micrococcal Nuclease Digestion Time Mononucleosome Chromatosome Core Particle Linker DNA (variable) Operational Definititions of Nucleosome Particles Chromatin 4
The 30 nm Chromatin fiber Compaction ratio =50
The 30 nm Chromatin Fiber Compaction ratio = 50 5
A Mitotic human chromosome DNA length:4.6x 10 bp=1.5 cm Chromosome length: 2 um 30 nm filament Compaction ratio=8000
A Mitotic Human Chromosome DNA length: 4.6 x 107 bp = 1.5 cm Chromosome length: 2 µm Compaction ratio = 8000 1 30 nm filament