The citric acid cycletricarboxylic acid (TCA) cycleKrebsCycle
The citric acid cycle tricarboxylic acid (TCA) cycle Krebs Cycle
The metabolism process after glycolysis under aerobic conditions: Under aerobic conditions, pyruvate from glycolysis is converted to acetyl.coenzyme A (acetyl-CoA) and oxidized to CO, in the tricarboxylic acid(TCA) cycle (also called the citric acid cycle)..TCA cycle are captured in the form of NADH and FADH2,and thesereduced coenzymes fuel the electron-transport pathway and oxidativephosphorylationto generate ATP.: Although two molecules of ATP come from glycolysis and two moredirectly out of the TCA cycle, most of the ATP arises from oxidativephosphorylation
The metabolism process after glycolysis under aerobic conditions • Under aerobic conditions, pyruvate from glycolysis is converted to acetylcoenzyme A (acetyl-CoA) and oxidized to CO2 in the tricarboxylic acid (TCA) cycle (also called the citric acid cycle). • TCA cycle are captured in the form of NADH and FADH2, and these reduced coenzymes fuel the electron-transport pathway and oxidative phosphorylation to generate ATP. • Although two molecules of ATP come from glycolysis and two more directly out of the TCA cycle, most of the ATP arises from oxidative phosphorylation
FIGURE 19.1 (a) Pyruvate produced in glycolysis is axidized in (b) the tricar-Glycolysis(a)boxylic acid (TCA) cycle. (c) Electrons liberated in this oxidation flow through theGlucostelectron-transport chain and drive the synthesis of ATP in oxidative phosphory-lation.In.eukaryotic cells, this overall process occurs in mitochondria.ADP+PNAD+NADHATPPyruvateNAD+NADHAcetyi-CoAOxidative(c)Electron transportphosphorylation(b)IntermembranespaceProtongradientHHI-H1154CitricMalateacidNADHcycletoghutarateNADHOADHADP+H.OATPPGTPGDP + PMitochondrialmatrix+[FADH2]H-NADH
The Citric Acid Cycle? Pyruvate from glycolysis is degraded to CO,·SomeATPisproduced·MoreNADHismade·NADHgoesontomakemoreATPinelectrontransportandoxidative phosphorylation
The Citric Acid Cycle • Pyruvate from glycolysis is degraded to CO2 • Some ATP is produced • More NADH is made • NADH goes on to make more ATP in electron transport and oxidative phosphorylation
The Citric Acid Cycle happened inmitochondrion matrix(Acetyl-CoA)MATRIXO-CondensationCH,-C-S.COACOA-SHHCH,-COO"234O=C-C00-HO-C-COO-citrateExracelulaCH,-COO-symthaseCH,-COO:Dehydration(Oxalcacetate)(Citrate)Dehydrogenation-H,OG--29:7kmoaconitasemalateCOOdehydrogenaseCH,COO-(Malate) HOCHCOOCH(cis-Aconitate)0-COO-COO:HydrationNADHfumaraseH,O54638aconitaseCOOHydratiorFADH2CHCH-COO(Fumarate)HCH-C-COONG-0.0NWmoCOOHO--COO: (Isocirate)MatrCEINN50-209kammogenas工isocitratgenatonInnerdehydrogenasemitochondralG-2.9dmmCH-COO"G33.5kamolOxidativemembranedecarbaxylasioncciwl-CoaCHketoglutaransynthotacocOdehCH-COO-inasOute(Succinate)COOcomplexchondrialCHCH,-COO-membrane-cooCOA-SHCHeoCS-CoAGOFCOA-SHGTP(t-Ketogiutarate)ADP(ATP)cO.0SubstrateOxidative(succinyl-CaA)ylation
The Citric Acid Cycle happened in mitochondrion matrix