C)维蒂希Wt)反应 C=O+ R2C-PR"3 C=CR2+ 0=PR"3 R Ylide Reagent R 含磷Yide试剂的制备 Ph3P+ RCH2X Ph3P-CH2R X (X: Cl, Br, D) Base PhP=CHR←PhsP-CHR Base: strong, such as BuLi, PhLi, NaNH2, NaCh2SoCH3 RCH2×:容易发生SN2反应的卤代烃
C)维蒂希(Wittig)反应 C R R O + R' 2C PR'' 3 C PR'' 3 R R CR' 2 + O Ylide Reagent 含磷Ylide试剂的制备 Ph3P + RCH2X Ph3P CH2R X (X: Cl, Br, I) Base Ph3P CHR Ph3P CHR (Base: strong, such as BuLi, PhLi, NaNH2 , NaCH2 SOCH3 ) RCH2X: 容易发生SN2反应的卤代烃
应用例子 Nachosch Ph3P+ CH 3 31-Ph3PCHRI DMSO Ph3P=CH 2 ≥=0+Ph3P=CHz DMSO CH 2 NaNH CHO h3PCH2 Ch3 Br Ph3P=CHCH 3 3 Benzene CH=CHCH
应用例子: O Ph3 P +CH3I Ph3 PCH3 I NaCH2 SCH3 O DMSO Ph3 P=CH2 + Ph3 P=CH2 DMSO CH2 Ph3 PCH2CH3 Br NaNH2 NH3 Ph3 P=CHCH3 CHO Benzene CH=CHCH3