3膜的合成与分选
3.膜的合成与分选
Nature401,625(1999 Medicine Nobel goes to pioneer of protein guidance mechanisms/ How do the proteins know where to go? How do they make their way? Nature 细胞中自组装和自组织问题的重要课 题之一是物质的分选、定向和转运, 是细胞自组装自组织过程的第一步 Gunter blobel
Medicine Nobel goes to pioneer of protein guidance mechanisms Nature 401, 625 (1999) How do the proteins know where to go? How do they make their way? ----Nature Gunter Blobel 细胞中自组装和自组织问题的重要课 题之一是物质的分选、定向和转运， 是细胞自组装自组织过程的第一步
Individual Proteins are transported within the pattern according to intrinsic signals. Signal sequences ---initiate translocation of proteins across specific membranes. Stop-transfer sequences ---interrupt the translocation process that was previously initiated by a signal sequence. Sorting sequences --act as determinants for posttranslocational traffic of subpopulations of proteins. Insertion sequences -- initiate unilateral integration of proteins into the lipid bilayer without the mediation of a distinct protein effector. --Gunter blobel(PANS Zz, 1980, 1496-1500)
# Individual Proteins are transported within the pattern according to intrinsic signals. Signal sequences --- initiate translocation of proteins across specific membranes. Stop-transfer sequences --- interrupt the translocation process that was previously initiated by a signal sequence. Sorting sequences --- act as determinants for posttranslocational traffic of subpopulations of proteins. Insertion sequences --- initiate unilateral integration of proteins into the lipid bilayer without the mediation of a distinct protein effector. ------- Gunter Blobel (PANS 77, 1980, 1496-1500)
蛋白质分选存在不同层次
蛋白质分选存在不同层次
蛋白质分选存在不同层次 ●由线粒体和叶绿体DNA编码的蛋白,则 在这些细胞器的核糖体中合成,因此这 些蛋白就直接编入线粒体和叶绿体空间 里( compartment ●在真核细胞中,大多数线粒体和叶绿体 蛋白,以及其它细胞器、颗粒和膜的蛋 白都是由核DNA编码,并在胞浆核糖体 中合成的。 将这些蛋白分选到其正确的方向,就需要多 重的分选信号及多步的分选活动
蛋白质分选存在不同层次 由线粒体和叶绿体DNA编码的蛋白，则 在这些细胞器的核糖体中合成，因此这 些蛋白就直接编入线粒体和叶绿体空间 里(compartment)。 在真核细胞中，大多数线粒体和叶绿体 蛋白，以及其它细胞器、颗粒和膜的蛋 白都是由核DNA编码，并在胞浆核糖体 中合成的。 ⚫ 将这些蛋白分选到其正确的方向，就需要多 重的分选信号及多步的分选活动