4.这种相互作用又影响 Cell exterior 了蛋白质两个跨膜域之 间的相互作用，导致底 物释放到细胞外。 Cell interior 2ADP+2P:← The strong interaction 2ATP 2H20 between the ATP- binding cassettes induces a change in the ATP ATP relation between the two membrane-spanning 图13.9ABC运输蛋白的作用机制。 domains,releasing the substrate to the outside of the cell
图13.9 ABC运输蛋白的作用机制。 4．这种相互作用又影响 了蛋白质两个跨膜域之 间的相互作用，导致底 物释放到细胞外。 The strong interaction between the ATP - binding cassettes induces a change in the relation between the two membrane-spanning domains, releasing the substrate to the outside of the cell
Cell exterion 5.ATP水解，释放ADP和 Cell interior in 无机磷酸，又将蛋白质结 2ADP +2P 构恢复到起始状态。 3 2ATP 2H20 The hydrolysis of ATP and the release of ADP and ATP ATP inorganic phosphate reset the transporter for another 图13.9ABC运输蛋白的作用机制。 cycle
图13.9 ABC运输蛋白的作用机制。 5．ATP水解，释放ADP和 无机磷酸，又将蛋白质结 构恢复到起始状态。 The hydrolysis of ATP and the release of ADP and inorganic phosphate reset the transporter for another cycle