Mitochondriadysfunctionimplicated in ADMitochondrial oxidative damage andADMitochondrial dynamics and ADMitochondrial targeted drugs/nutrientsand prevention and treatment of AD
• Mitochondrial oxidative damage and AD • Mitochondrial dynamics and AD • Mitochondrial targeted drugs/nutrients and prevention and treatment of AD Mitochondria dysfunction implicated in AD
OxidativedamageofmitochondriaandADOxidative damage and dysfunction of mitochondria may be the keyfactors causing the pathogenesis of ADThe characteristic pathology of AD, such as oxidative stress, may exist inneurons before the deposit of ApOxidative stress is an important factor to promote the deposition ofAbetaThere is significant oxidative damage to mitochondria in neurons inalzheimer'spatientsWidespread mitochondrial oxidative damage exists in the brain of ADpatientsMitochondrial oxidativedamageinduced by ApOther AD-related proteins, such as preselin 1 mutation, can causedisorder of mitochondrial Ca 2+regulation and synaptic mitochondrialCa 2+ overload, thus inducing apoptosis
Oxidative damage of mitochondria and AD • Oxidative damage and dysfunction of mitochondria may be the key factors causing the pathogenesis of AD – The characteristic pathology of AD, such as oxidative stress, may exist in neurons before the deposit of Aβ. – Oxidative stress is an important factor to promote the deposition of A beta • There is significant oxidative damage to mitochondria in neurons in alzheimer's patients – Widespread mitochondrial oxidative damage exists in the brain of AD patients – Mitochondrial oxidative damage induced by Aβ – Other AD-related proteins, such as preselin 1 mutation, can cause disorder of mitochondrial Ca 2+ regulation and synaptic mitochondrial Ca 2+ overload, thus inducing apoptosis
Mitochondrial dynamicsand ADMitochondrial dynamics is a hot topic inalzheimer'sresearchDRPl and other molecules may be involvedin themorphological changes,disruption and fusionregulation disorders of mitochondria in Alzheimer'sdisease.Mitochondrial autophagy and alzheimer's diseaseMitochondrial dynamic changes are newtargets fordisease prevention and treatment
Mitochondrial dynamics and AD Mitochondrial dynamics is a hot topic in alzheimer's research ⚫ DRP1 and other molecules may be involved in the morphological changes, disruption and fusion regulation disorders of mitochondria in Alzheimer's disease. ⚫ Mitochondrial autophagy and alzheimer's disease ⚫ Mitochondrial dynamic changes are new targets for disease prevention and treatment
Mitochondriamaybeanintracellulartargetfor the prevention andtreatment of ADPossible mechanism ofmitochondrial nutrients1) Enhancing Substrates and Coenzymes of Mitochondrial Enzymes2) Induction of PhaseIIenzymes enhances cell antioxidant protection3) Scavenging free radicals reduces the accumulation of oxidativeproductsinmitochondria4)Repairofmitochondrialmembrane-5) Cell level:Activate mitochondrial production and degradation(plant) estrogen Protective mitochondrial osmotic transport pore drugMitochondria targeted antioxidant drugsMitCoQ,MitoVitE
Mitochondria may be an intracellular target for the prevention and treatment of AD • Possible mechanism of mitochondrial nutrients – 1）Enhancing Substrates and Coenzymes of Mitochondrial Enzymes – 2）Induction of Phase II enzymes enhances cell antioxidant protection – 3）Scavenging free radicals reduces the accumulation of oxidative products in mitochondria – 4）Repair of mitochondrial membrane –5）Cell level: Activate mitochondrial production and degradation. • (plant) estrogen Protective mitochondrial osmotic transport pore drug • Mitochondria targeted antioxidant drugs MitCoQ, MitoVitE
EvidenceonMt-ADOxidativestressMtdynamicsEstrogen
Evidence on Mt-AD Oxidative stress Mt dynamics Estrogen