易感儿童在感染(环境因素)作用下出现免疫 异常的结果 Exaggerated immune reactivity in predisposed children in response to exposure to certain infections(environmental factors)
易感儿童在感染（环境因素）作用下出现免疫 异常的结果 Exaggerated immune reactivity in predisposed children in response to exposure to certain infections (environmental factors)
病理变化 Pathologic changes 关节:绒毛状增厚为特征的滑膜炎 Synovitis characterized by villous hypertrophy 滑膜下组织充血、水肿 Hyperemia and edema of the subsynovial tissues 血管翳形成 Pannus formation 关节软骨和邻近骨组织的破坏 Erosion of articular cartilage and contiguous bone
病理变化Pathologic changes 关节：绒毛状增厚为特征的滑膜炎 Synovitis characterized by villous hypertrophy 滑膜下组织充血、水肿 Hyperemia and edema of the subsynovial tissues 血管翳形成 Pannus formation 关节软骨和邻近骨组织的破坏 Erosion of articular cartilage and contiguous bone
皮下结节: Subcutaneous( Rheumatoid) nodules 见于肘关节伸侧面 Found on extensor surfaces of elbows 眼部病变 虹膜睫状体炎,尤见于少关节型病例 iridocyclitis mainly in the cases of oligoarthritis
皮下结节：Subcutaneous (Rheumatoid) nodules 见于肘关节伸侧面 Found on extensor surfaces of elbows 眼部病变 虹膜睫状体炎，尤见于少关节型病例 Iridocyclitis ,mainly in the cases of oligoarthritis
临床表现 Clinical manifestations 1全身型:占10%-20%JRA病例 Systemic-onset disease, 10%-20%cases 发热:呈弛张热型是此型特点,体温高峰达40 热退时一般情况好 Fever: Characterized by a remmitent fever with temperature spikes to 40C. Present well when fever going down
临床表现Clinical manifestations 1.全身型 ：占10％-20％JRA病例 Systemic-onset disease，10％-20％ cases 发热：呈弛张热型是此型特点，体温高峰达40oC, 热退时一般情况好 Fever: Characterized by a remmitent fever with temperature spikes to 40oC .Present well when fever going down
41 40 肛门体温C 39 38 37 36 Ta 3岁JRA女孩 发烧多天 经反复应用退烧药无效
肛 门 体 温 oC 3 岁JRA女孩： －发烧多天 －经反复应用退烧药无效