上降充通大警 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Non-steroidal anti-inflammatory drugs (NSAIDs) An antipyretic effect:this is partly due to a decrease in the mediator prostaglandin that is responsible for elevating the hypothalamic set- point for temperature control in fever. Endogenous pyogen(IL-1,TNF,IFN,IL-6) →BBB→CNS(PEG,Na+/Ca2+,cAMP,CRH ◆fever
Non-steroidal anti-inflammatory drugs (NSAIDs) • An antipyretic effect: this is partly due to a decrease in the mediator prostaglandin that is responsible for elevating the hypothalamic setpoint for temperature control in fever. • Endogenous pyogen(IL-1,TNF,IFN, IL-6) BBB CNS(PEG, Na +/Ca2+, cAMP,CRH) fever
上游充通大淫 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Classification Non-selective COX inhibitor selectivity Selective COX inhibitor Salicylates (Aspirin) chemcial Anilines (Acetaminophen) constitution Indoleacetic acid(Indomethacin) et al AO TONG
Classification Non-selective COX inhibitor Selective COX inhibitor Salicylates (Aspirin) Anilines (Acetaminophen) Indoleacetic acid (Indomethacin) et al selectivity chemcial constitution