UCLAnnual mortality rates from CV disease0.28%General population32X33X2X9.12%Haemodialysis9.24%Peritoneal dialysisTransplant recipients 0. 54%Levey et alAJKD 1998;32:853-906
Annual mortality rates from CVdisease 0.28% 9.12% 9.24% • Generalpopulation • Haemodialysis • Peritonealdialysis • Transplant recipients0.54% LeveyetalAJKD 1998;32:853-906 32X 33X 2X
UCLCardiovascular mortality in dialysis patientswithrenaldysfunction100Levey et alAJKD 1998:32:853(%) en10+ Dialysis MaleDialysis Femald0.1+ Control Male--Control Female0.01 Transplant pts器25-34 35-44 45-54 55-64 65-74 75-84>85Age (years)
Cardiovascular mortality in dialysis patients with renal dysfunction Age (years) Annual Mortality (%) 0.01 0.1 10 1 100 25-34 35-44 45-54 55-64 65-74 75-84 >85 Dialysis Male Dialysis Female Control Male Control Female LeveyetalAJKD 1998;32:853 Transplant pts
UCLChronic Renal DiseaseNephrotic syndromeChronic renal failureRenal transplantation(Consequence)+VLDLVLDL remnants(prim ary)Small dense LDLHDL*accumulationof lipid&cell debrisInflammatory cell infiltratimAtherosclerosisSMC proliferation
VLDL VLDL remnants Small dense LDL HDL Atherosclerosis Chronic Renal Disease Nephrotic syndrome Chronic renal failure Renal transplantation (Consequence) (prim ary) accumulationoflipid&celldebris Inflammatory cell infiltration SMC proliferation
UCLTotal Cholesterol and Cardiovascular Mortalityamong 350,000 men: MRFITProspective Study2.0ee1.00.5-6. 07.04.05.0Usual total cholesterol (mmol/1)Martin et al, Lancet1986;2(8513) :933-936
Total Cholesterol and Cardiovascular Mortality among 350,000 men: MRFIT Prospective Study 2.0 1.0 0.5 4.0 RelativeriskofCHD death 5.0 6.0 7.0 Usual total cholesterol (mmol/l) Martin et al, Lancet1986;2(8513):933-936
UCLTotal Cholesterol and Cardiovascular Mortalityin dialysis patients40ee Overall(Sedo e)3020-10-0-240120140160180200220Cholesterol (mg/dl)Liuet al, JAMA 2004;291:451-459
Liuetal,JAMA 2004;291:451-459 120 140 160 180 200 220 240 Cholesterol(mg/dl) Cardiovascularmortality rate (per 100patients) Total Cholesterol and Cardiovascular Mortality in dialysis patients 40 Overall 30 20 10 0