上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Mechanisms of Action:Loop diuretics Ascending loop contains Na+-K+-2Cl-cotransporter from lumen to ascending limb cells Loop diuretic blocks cotransporter Nat,K,and Cl remain in lumen, excreted along with water Thick ascending limb cell Tubular fluid Peritubular capillary Loop diuretic Na K Na 2C- +10mV Na,K+, Mg2+,Ca2+ H2O Apical cell Basolateral membrane cell membrane Elsevier 2005.Minneman Wecker:Brody's Human Pharmacology 4e www.studentconsult.com
Mechanisms of Action: Loop diuretics Ascending loop contains Na+ - K+ - 2Cl- cotransporter from lumen to ascending limb cells Loop diuretic blocks cotransporter Na +, K +, and Cl- remain in lumen, excreted along with water
上降充通大警 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Loop Diuretics:Drug Effects Potent diuresis and subsequent loss of fluid Decreased fluid volume causes: a Reduced BP Reduced pulmonary vascular resistance Reduced systemic vascular resistance 0 Reduced central venous pressure Reduced left ventricular end-diastolic pressure Potassium depletion HO TONG
Loop Diuretics: Drug Effects Potent diuresis and subsequent loss of fluid Decreased fluid volume causes: Reduced BP Reduced pulmonary vascular resistance Reduced systemic vascular resistance Reduced central venous pressure Reduced left ventricular end-diastolic pressure Potassium depletion