上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Electrolyte Transport Mechanisms Tubular fluid Nat/spump caillary Channel 6 A Na+ Cotransport ⑧ Na ② 3 Na [Na'] Countertrapsport Na+ © Na Lateral intercellular space H2O Tight junction X=glucose,amino acids,phosphate, etc. Net Na +H2O Transport Apical cell Basolateral membrane cell membrane Elsevier 2005.Minneman Wecker:Brody's Human Pharmacology 4e www.studentconsult.com
Electrolyte Transport Mechanisms Channel Cotransport Countertransport Na+/K+ pump X = glucose, amino acids, phosphate, etc
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Summary of sites of renal reabsorption of filtrate Water filtered at 125 ml/min 8 100 80 70% 60 A 40 20 15% 14% 1% Proximal Loop of Distal and I Excreted Henle collect.duct Sodium filtered at 17.5 mEq/min 100 80 70% 60 B 40 25% 20 4.5% 0.5% Proximal Loop of Distal and Excreted Henle collect.duct O Elsevier 2005.Minneman Wecker:Brody's Human Pharmacology 4e www.studentconsult.com
Summary of sites of renal reabsorption of filtrate
上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Diuretic Agents ■Loop diuretics Thiazide and thiazide-like diuretics Potassium-sparing diuretics Carbonic anhydrase inhibitors Osmotic diuretics JIAO TONG UNIVEKS
Diuretic Agents Loop diuretics Thiazide and thiazide-like diuretics Potassium-sparing diuretics Carbonic anhydrase inhibitors Osmotic diuretics
7 上游充通大辛 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 eypes and Names of Diuretics Example Sites of Action Osmotic agents Mannitol Proximal tubule Descending loop Collecting duct Carbonic Acetazolamide Proximal tubule anydrase inhib Thiazides Hydrochlorothiaz Distal convoluted ide tubule Loop diuretic Ethacrynic acid Loop of Henle Furosemide K+sparing Spironolactone Collecting tubule Amiloride
Types and Names of Diuretics Osmotic agents Mannitol Proximal tubule Descending loop Collecting duct Carbonic anydrase inhib. Acetazolamide Proximal tubule Thiazides Hydrochlorothiaz ide Distal convoluted tubule Loop diuretic Ethacrynic acid Furosemide Loop of Henle Type Example Sites of Action K+ - sparing Spironolactone Amiloride Collecting tubule
上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Nephron sites of action of diuretics Afferent Distal convoluted arteriole tubule Glomerulus Proximal convoluted tubule Cortical Efferent collecting arteriole tubule Thick ascending Proximal limb straight tubule Medullary collecting tubule Site of diuretic action Carbonic anhydrase inhibitors ☑ Osmotic diuretics Thin descending Loop diuretics limb Thin ascending Thiazide diuretics limb K'-sparing diuretics Elsevier 2005.Minneman Wecker:Brody's Human Pharmacology 4e www.studentconsult.com
Nephron sites of action of diuretics