Chapter 2 Protein Section 3 Proteins: Secondary, Tertiary, and Quaternary Structure
Chapter 2 Protein Section 3 Proteins: Secondary, Tertiary, and Quaternary Structure
Outline 6.1 Forces Influencing Protein Structure 6.2 Role of the Amino Acid sequence in Protein structure 6. 3 Secondary structure of Proteins 6.4 Protein Folding and Tertiary Structure 6.5 Subunit Interactions and Quaternary Structure
Outline 6.1 Forces Influencing Protein Structure 6.2 Role of the Amino Acid Sequence in Protein Structure 6.3 Secondary Structure of Proteins 6.4 Protein Folding and Tertiary Structure 6.5 Subunit Interactions and Quaternary Structure
6.1 The weak forces What are they What are the relevant numbers van der waals:0,4-4 kj/mol hydrogen bonds: 12-30 kJ/mol ionic bonds: 20 kJ/mol hydrophobic interactions: <40 kJ/mol
6.1 The Weak Forces What are they? What are the relevant numbers? • van der Waals: 0.4 - 4 kJ/mol • hydrogen bonds: 12-30 kJ/mol • ionic bonds: 20 kJ/mol • hydrophobic interactions: <40 kJ/mol
Com parison of bond energies covalent and non-covalent Non-covalent Inter actions 200 hydroph obic interaction: si-o order ing of water around nonpolar groups ts decreased as thes e 150 groups become buried within molecule C-F hydrogen bond: associations b etween E100 C-OH polar groups e containing O and N electrostatic bond: 50 C salt bridges between c- no positively and neg atively m charged groups van der waals bond: weak associations between nonpolar groups
van der waals(落德华力) 58 Covalent van der Waals radius radius 0062mm (0.14nm
van der Waals(范德华力）: