Squamous cell carcinomaTracheaLungSquamous cellcarcinomaBronchiFADAMThe major pathologic features are keratinization,cellular stratification, andintercellularbridgesAccount for about 20% of all cases of lung cancer and 70% of non-small celltumors.Two-thirdsarelocatedcentrallynearthehilumandone-thirdperipherallyThe growthrateand therate of metastasismetastasistend tobe slowerthanthoseofotherlungtumors.11
11 ❑The major pathologic features are keratinization, cellular stratification, and intercellular bridges. ❑Account for about 20% of all cases of lung cancer and 70% of non-small cell tumors. ❑Two-thirds are located centrally near the hilum and one-third peripherally. ❑The growth rate and the rate of metastasis metastasis tend to be slower than those of otherlung tumors. Squamous cell carcinoma
AdenocarcinomaTracheaLungAdenocarcinomaBronchiADAMConstitute30% of lung cancers and 60% of non-small cell tumors,characterizedasacinar,papillary,andbronchoalveolar.12
12 Adenocarcinoma ❑Constitute 30% of lung cancers and 60% of non-small cell tumors, characterized as acinar, papillary, and bronchoalveolar
LargeCell CarcinomaLargecell carcinomas are composed of largepolygonal spindleoroval cells arranged in sheets,nests or clustersltisseenperipherallyandislesscommon13
13 Large Cell Carcinoma ❑Large cell carcinomas are composed of large polygonal spindle or oval cells arranged in sheets, nests or clusters. ❑It is seen peripherally and is less common
SmallCell LungCancer(SCLC)Small cell (oat cell) carcinomas have small, round nuclei with nuclearchromatin and cytoplasm.They are so biologically and clinically distinct from non-small cell lungcancer (NSCLC).Small cell carcinomas comprise 15-20%ofall lungcancers.They occur centrally,metastasize early, and are the most resistant to14combined-modalitytreatment
14 Small Cell Lung Cancer (SCLC) ⚫ Small cell (oat cell) carcinomas have small, round nuclei with nuclear chromatin and cytoplasm. ⚫ They are so biologically and clinically distinct from non-small cell lung cancer (NSCLC). ⚫ Small cell carcinomas comprise 15-20% of all lung cancers. ⚫ They occur centrally,metastasize early, and are the most resistant to combined-modality treatment
Lung CancerSigns & Symptoms15
15 Lung Cancer Signs & Symptoms