S Pneumoniae virulence Factors Polysaccharide Capsule that prevents phagocytosis by the hosts immune cells surface proteins that prevent the activation of complement-mediated opsonization pilli that enable s pneumoniae to attach to epithelial cells in the upper respiratory tract
S. Pneumoniae Virulence Factors Polysaccharaide Capsule surface proteins pili • that prevents phagocytosis by the host's immune cells • that prevent the activation of complement-mediated opsonization. • that enable to attach to epithelial cells in the upper respiratory tract S. pneumoniae
Streptococcus Pneumoniae Pathogenesis Causes 60-70% of all bacterial pneumonia Pneumococci produce their disease through their ability to multiply in tissues From the respiratory tract the infection can reach other sites such as sinuses and middle ear. Infections sometimes can spread from the mastoid to the meningitis, and sometimes bacteria enter blood stream, resulting bacteremia Severe complications include meningitis endocarditis, and septic arthritis
Streptococcus Pneumoniae Pathogenesis • Causes 60-70% of all bacterial pneumonia • Pneumococci produce their disease through their ability to multiply in tissues. • From the respiratory tract the infection can reach other sites such as sinuses and middle ear. Infections sometimes can spread from the mastoid to the meningitis, and sometimes bacteria enter blood stream, resulting bacteremia. • Severe complications include meningitis, endocarditis, and septic arthritis