Diagnostic Criteria WHO1999 IGT FPG<7mmol/L -2-h PG278mmol/ and <11.1 mmol/L IFG -FPG26. 1 mmol/L and <7.0mmol/L
Diagnostic Criteria WHO1999 IGT -FPG<7mmol/L -2-h PG≥7.8mmol/L and <11.1mmol/L IFG -FPG≥6.1mmol/L and <7.0mmol/L
Laboratory Findings Urinary glucose Urinary ketone Blood glucose(FPG and 2-hPG) HbAlc and FA(fructosamine) OGTT Insulin/cp releasing test
Laboratory Findings Urinary glucose Urinary ketone Blood glucose (FPG and 2-hPG) HbA1c and FA(fructosamine) OGTT Insulin / CP releasing test
classification (1) Type 1 diabetes B-cell destruction, usually leading to absolute deficiency Immune-mediated diabetes ldiopathic diabetes Type 2 diabetes Ranging from predominantly insulin resistance with relative insulin deficiency to predominantly an insulin secretory defect with insulin resistance
Classification (1) Type 1 diabetes β-cell destruction, usually leading to absolute deficiency Immune-mediated diabetes Idiopathic diabetes Type 2 diabetes Ranging from predominantly insulin resistance with relative insulin deficiency to predominantly an insulin secretory defect with insulin resistance
Classification(2) Other specific types of diabetes Due to other causes, e.g. genetic defects in insulin action diseases of the exocrine pancreas, drug or chemical induced Gestational diabetes mellitus(GDM) diagnosed during pregnancy
Classification (2) Other specific types of diabetes Due to other causes, e.g.,genetic defects in insulin action, diseases of the exocrine pancreas, drug or chemical induced Gestational diabetes mellitus(GDM) diagnosed during pregnancy
Etiologic classification of diabetes mellitus(1) IType 1 diabetes( B-cell destruction, usually leading to absolute insulin deficiency A immune mediated B Idiopathic Il Type 2diabetes( may range from predominantly insulin resistance with relative insulin deficiency to a predominantly secretory defectwith insulin resistance) lll.Other specific types A genetic defects of B-cell function 1. Chromosome 12, HNF-1a MODY3 2. Chromosome 7, glucokinase(MODY2) 3. Chromosome 20, HNF-4a(MODY1) 4. Mitochondrial dNA 5. others B. Genetic defects in insulin action 1. Type A insulin resistance 2. Leprechaunism 3. Rabson-Mendenhall syndrome 4. Lipoatrophic disease 5. Others C Diseases of the exocrine pancreas 1. Pancreatitis 2. Trauma/ pancreatectomy 3. Neoplasia Cystic fibrosis 5. Hemochromatosis 6. Fibrocalculous pancreatopathy 7. Others
Etiologic classification of diabetes mellitus(1) I.Type 1diabetes ( -cell destruction, usually leading to absolute insulin deficiency ) A. immune mediated B. Idiopathic II.Type 2diabetes ( may range from predominantly insulin resistance with relative insulin deficiency to a predominantly secretory defect with insulin resistance ) III.Other specific types A. genetic defects of -cell function 1. Chromosome 12, HNF-1 (MODY3) 2. Chromosome 7, glucokinase (MODY2) 3. Chromosome 20, HNF-4 (MODY1) 4. Mitochondrial DNA 5. Others B. Genetic defects in insulin action 1. Type A insulin resistance 2. Leprechaunism 3. Rabson- Mendenhall syndrome 4. Lipoatrophic disease 5. Others C. Diseases of the exocrine pancreas 1. Pancreatitis 2. Trauma / pancreatectomy 3. Neoplasia 4. Cystic fibrosis 5. Hemochromatosis 6. Fibrocalculous pancreatopathy 7. Others