Bronchial asthma Department of respiration Kong Lingfei
Bronchial asthma Department of respiration Kong Lingfei
Asthma human killer
Asthma：human killer!
Background of asthma Prevalence: in the world: 1.6 hundred million in China:1-3 2 in Shenyang: 1.24%(1999) GINA: Global Initiative for Asthma (1994) WHO/HLBI Bronchial asthmatic diagnosis guideline(1997) Chinese Medical academy
Background of asthma Prevalence ：in the world: 1.6 hundred million in China: 1～3 ％ in Shenyang: 1.24 ％（1999） GINA: Global Initiative for Asthma（1994） WHO/HLBI Bronchial asthmatic diagnosis guideline (1997） Chinese Medical Academy
Definitions of asthma Chronic airway inflammation Broncho-hyperresponsiveness, BHR · Airflow limitation
Definitions of asthma • Chronic airway inflammation • Broncho-hyperresponsiveness, BHR • Airflow limitation
Mechanism: allergy theory antigen antigen again atopy→ ige antibody→→ mast cells, basophils ↓ histamine inflammatory media LTs PAF ECP immediate asthmatic reaction AR bronchial smooth muscle spasm airway narrow
Mechanism: allergy theory antigen antigen ↓ ↓again atopy→IgE antibody→mast cells, basophils ↓ histamine inflammatory media LTs ↓ PAF ECP immediate asthmatic reaction, IAR ↓ bronchial smooth muscle spasm airway narrow