Alkyl Halides Other halo-substituted compounds are used as medicines and food additives Sucralose,marketed as Splenda,is 600 times as sweet as ordinary table sugar,sucrose 三氯蔗糖，蔗糖素，代糖 CH2CI HOCH2 HO CH2CI HO HO Sucralose
Other halo-substituted compounds are used as medicines and food additives ▪ Sucralose, marketed as Splenda, is 600 times as sweet as ordinary table sugar, sucrose Alkyl Halides 三氯蔗糖，蔗糖素，代糖
Naturally Occurring Organohalides Marine corals secrete organohalogen compounds that act as a feeding deterrent to fish. More than 5000 organohalides have been found to occur naturally,and tens of thousands more surely exist
More than 5000 organohalides have been found to occur naturally, and tens of thousands more surely exist. Naturally Occurring Organohalides
Br Br Halomon The pentahalogenated alkene halomon has been isolated from the red alga Portieria hornemannii and found to have anticancer activity against several human tumor cell lines. Some naturally occurring organohalides are produced in massive quantities.从海洋红藻松香藻中分离的抗癌症活性成分 Forest fires,volcanoes,and marine kelp release up to 5 million tons of CHaCl per year,for example,while annual industrial emissions total about 26,000 tons. Termites are thought to release as much as 108 kg of chloroform per year.白蚁
The pentahalogenated alkene halomon has been isolated from the red alga Portieria hornemannii and found to have anticancer activity against several human tumor cell lines. Some naturally occurring organohalides are produced in massive quantities. Forest fires, volcanoes, and marine kelp release up to 5 million tons of CH3Cl per year, for example, while annual industrial emissions total about 26,000 tons. Termites are thought to release as much as 108 kg of chloroform per year.白蚁 从海洋红藻松香藻中分离的抗癌症活性成分
Sec 1 PREPARATION AND PHYSICAL PROPERTIES ■PREPARATION .Halogenation(Allylic Halogenation) oWith HX ●From alcohol Diazonium coupling (for aryl halide only)
Sec 1 PREPARATION AND PHYSICAL PROPERTIES ◼PREPARATION ⚫Halogenation(Allylic Halogenation) ⚫With HX ⚫From alcohol ⚫Diazonium coupling (for aryl halide only)
■l.Halogenation H H h +Br2 Br HB anhy.AICla Highly selective:Bromination of 3 C CH3 CH3 CH一C-H +Br2 hv CHC-Br HBr CH3 CH3 90%
◼Highly selective: Bromination of 3 C 90% CH3 C + HBr CH3 CH3 Br h CH3 C + Br2 CH3 CH3 H RH + Cl 2 RCl + HCl u.v. C Cl l 2 anhy. AlCl 3 ◼ 1. Halogenation + HBr H Br h + Br2 H H