Organic Chemistry with BiologicalApplications,3rEdition John McMurry Chapter 09 Aromatic Compounds Aromatic rings are a common part of many biological structures and are particularty important in the chemistry of nucleic acids and several amino acids. How and why aromatic compounds are different from such apparently related compounds as alkenes
Chapter 09 Aromatic Compounds Organic Chemistry with Biological Applications, 3 rd Edition John McMurry Aromatic rings are a common part of many biological structures and are particularly important in the chemistry of nucleic acids and several amino acids. How and why aromatic compounds are different from such apparently related compounds as alkenes
JOHN MCMURRY CHAPTER 9 Aromatic Compounds Organic Chemistry with Biological Applications Homework:P294:9.15:9.16P302:9.20 P307:9.24:P318e:9.56:P318i:9.74:9.81 Key Notes Aromaticity;Resonance Structure;Huckel rulej Electrophilic substitutions;Activating group;
Key Notes Aromaticity; Resonance Structure; Hückel rule; Electrophilic substitutions; Activating group; Homework： P294: 9.15; 9.16； P302: 9.20; P307:9.24； P318e：9.56； P318i: 9.74; 9.81;
Main Contents Structure Stability Aromaticity reactivity Preparation of Ar compounds Electrophilic substitutions Effects of substituents on E.S. Synthesis of mono-,di-and tri-substituted benzenes ■Other reactions Oxidation and reduction Nucleophilic Substitution
Main Contents ◼Structure & Stability ◼Aromaticity & reactivity ◼Preparation of Ar compounds ◼Electrophilic substitutions ◼Effects of substituents on E.S. ✓Synthesis of mono-, di- and tri-substituted benzenes ◼Other reactions ✓Oxidation and reduction ✓Nucleophilic Substitution
Present Days of Organic Chemistry Aromatic Compounds Benzene Found to cause bone marrow depression Leads to leukopenia,or lowered white blood cell count,on prolonged exposure Many naturally occurring compounds are aromatic in part Steroidal hormone estrone Atorvastatin (Lipitor)-a cholesterol-lowering drug CH(CH3)2 H OH H OH CH3 CO2H HO Estrone Atorvastatin (Lipitor)
Aromatic Compounds ▪ Benzene ▪ Found to cause bone marrow depression ▪ Leads to leukopenia, or lowered white blood cell count, on prolonged exposure ▪ Many naturally occurring compounds are aromatic in part ▪ Steroidal hormone estrone ▪ Atorvastatin (Lipitor) – a cholesterol-lowering drug Present Days of Organic Chemistry
Review:Naming Aromatic Compounds Disubstituted benzenes Named using one of the prefixes 1.ortho-(o-) 2.meta-(m-） CH3 3.para-(p-） ortho-Dichlorobenzene meta-Dimethylbenzene para-Chlorobenzaldehyde 1,2 disubstituted (meta-xylene) 1,4 disubstituted 1,3 disubstituted
Disubstituted benzenes ▪ Named using one of the prefixes 1. ortho- (o-) 2. meta- (m-) 3. para- (p-) Review: Naming Aromatic Compounds