1980 Noble prize (Baruj Benacerraf)(Jean Dausset)(George D Snell)
(Baruj Benacerraf ) （Jean Dausset）（George D. Snell) 1980 Noble prize
Major Histocompatibilty Complex, MHC 1. Discovery of MHC 2. MHC Genes 3. Binding of Peptides to MHC Molecules 4. MHC polymorphism 5. Function and significance
Major Histocompatibilty Complex, MHC 1. Discovery of MHC 2. MHC Genes 3. Binding of Peptides to MHC Molecules 4. MHC polymorphism 5. Function and significance
MHC of human HUMAN CHROMOSOME 6 HLA Complex 4000kl Class 1000kb LOnOke 2000kb MHC II MHCII MHC I Loci Centromere Human HLA complex Complex HLA MHC class III Region DP )0 DR C4. C2. BI B C Gene DP DO DR INF-O products ap op op C proteins TNF阝 HLA-B HLA-C HLA-A
MHC II MHC III MHC I MHC of human
E Xpression O Because MHC molecules are required to present antigens to Tlymphocytes, the expression of these proteins in a cell determines whether foreign(e.g, microbial) antigens in that cell will be recognized by t cells O There are several important features of the expression of MHC molecules that contribute to their role in protecting individuals from diverse microbial infections
Because MHC molecules are required to present antigens to T lymphocytes, the expression of these proteins in a cell determines whether foreign (e.g., microbial) antigens in that cell will be recognized by T cells. There are several important features of the expression of MHC molecules that contribute to their role in protecting individuals from diverse microbial infections. Expression
Expression O Class I molecules are constitutively expressed on virtually all nucleated cells O Class II molecules are expressed only on dendritic cells, B lymphocytes, macrophages, and a few other cell types
Class I molecules are constitutively expressed on virtually all nucleated cells. Class II molecules are expressed only on dendritic cells, B lymphocytes, macrophages, and a few other cell types. Expression