MHC of mice H-2( Histocompatibility-2 O a single genetic region is identified by Snell's group which is primarily responsible for rapid rejection of tissue grafts, and this region was called the major histocompatibility locus The particular locus encodes a blood group antigen called antigen Il, and therefore this region was named histocompatibility-2, or simply H-2
H-2 ( Histocompatibility-2) A single genetic region is identified by Snell's group, which is primarily responsible for rapid rejection of tissue grafts, and this region was called the major histocompatibility locus. The particular locus encodes a blood group antigen called antigen II, and therefore this region was named histocompatibility-2, or simply H-2. MHC of mice
MHC of human HLA ( Human leukocyte antigen) Discovered by searching for cell surface molecules in one individual that would be recognized as foreign by another individual O leukocyte because the antibodies tested by binding to the leukocytes of other individuals. and antigens because the molecules were recognized by Jean dausset antibodies
Jean Dausset HLA ( Human leukocyte antigen) Discovered by searching for cell surface molecules in one individual that would be recognized as foreign by another individual leukocyte because the antibodies were tested by binding to the leukocytes of other individuals, and antigens because the molecules were recognized by antibodies MHC of human
O HLa proteins and the mouse H-2 proteins had essentially identical structure Genes encoding hla are homologous to the H-2 genes O They are all called MHC genes
HLA proteins and the mouse H-2 proteins had essentially identical structure. Genes encoding HLA are homologous to the H-2 genes. They are all called MHC genes
Immune response genes O Inbred strains of guinea pigs and mice differed in their ability to make antibodies against some simple synthetic polypeptides Responsiveness was inherited as a dominant mendelian trait O The relevant genes were called immune (Baruj Benacerraf) response (r genes, and they were all found to map to the mhc
(Baruj Benacerraf ) Inbred strains of guinea pigs and mice differed in their ability to make antibodies against some simple synthetic polypeptides Responsiveness was inherited as a dominant mendelian trait The relevant genes were called immune response (Ir) genes, and they were all found to map to the MHC Immune Response Genes
Immune Response genes O These immune response(Ir)genes, are in fact, MHC genes that encode MHC molecules that differ in their ability to bind and display peptides derived from various protein antigens
These immune response (Ir) genes, are, in fact, MHC genes that encode MHC molecules that differ in their ability to bind and display peptides derived from various protein antigens. Immune Response Genes