.Neurotransmitters secreted by enteric neurons-Ach: Stimulatory-NE: Inhibitory-Others: Substance P, Nitric oxide, Vasoactiveintestinal polypeptide (ViP), Opioid peptideserotonin,histamine,ATP
• Neurotransmitters secreted by enteric neurons – Others: Substance P, Nitric oxide, Vasoactive intestinal polypeptide (VIP), Opioid peptide, serotonin, histamine, ATP. – Ach: Stimulatory – NE: Inhibitory
Il.Hormonal Regulation-GlhormonesThe hormones synthesized by a large number ofendocrine cells within the gastrointestinal tractS8Brain-gut peptides:?a number of the classicalGl hormones are alsosynthesized in the brain.闭合型开放型图6-4消化道内分泌细胞形态的模式图
The hormones synthesized by a large number of endocrine cells within the gastrointestinal tract. III. Hormonal Regulation — GI hormones • Brain-gut peptides: a number of the classical GI hormones are also synthesized in the brain
Physiological Functions- Control of the digestive function_ The release of other hormones_ Trophic action
– Control of the digestive function – The release of other hormones – Trophic action Physiological Functions
FourmainHormonesGallbladder/Liver·GastrinStomachPancreas·Cholecystokinin·Secretin·Gastricinhibitorypolypeptide(GIP）
• Gastric inhibitory polypeptide (GIP) Four main Hormones • Gastrin • Cholecystokinin • Secretin
(1)GastrinParietalcell- is a peptide hormone,releasedby G cells in the pyloric antrum(Gastrin)of the stomach, duodenum, andHthe pancreas.(Endocrinc)FunctionsBloodCirculationStimulates secretion of gastricDigested protein;Gastrin (G-17)acid (HCl) and pepsinogen.AminoAcidsPromote sphincters'contractionin gastric antrum and pylorusG cellGastrinAids in gastric motilityProliferation of gastric epitheliumLumenofAntrum
Proliferation of gastric epithelium (1) Gastrin Stimulates secretion of gastric acid (HCl) and pepsinogen. - is a peptide hormone, released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas. Aids in gastric motility. Functions Promote sphincters’ contraction in gastric antrum and pylorus