HUMAN PHYSIOLOGY PPT Presentation by Chen Qi Chapter 11 Endocrine Physiology Physiological Department of Medical College, Yangzhou University
Generalintroductionofhormone1.Classificationofhomomesl.Classification of hormone1.l peptide hormone : most, water-soluble, transported freely1.2 amine hormonedopaminethyroid hormones and catecholaminesepinephrinenorepinephrinefat-solublewater-soluble1.3 steroid hormone :derived from cholesterol, fat-solublecortisol, aldosterone. 1,25-vitamin D and sex hormones
2. Mechanisms of hormone action2.1 signal transduction mechanism : water-soluble2.2 gene expression mechanism : fat-soluble3.Deliveryofhormoneendocrineparacrineautocrineneuroendocrine
Hypothalamus and pituitary gland1.Hypothalamic-anterior pituitary systemTRH-TSH-THsCRH-ACTH-cortsolGHRHGHIH-GHPRH/PIH-prolactinGnRH-FSH. LH- sex hormones
Growth hormone (somatotropin)1.Functions) promote growth : especially bone and soft tissuemediated by insulin-like growth factors (IGF)2) metabolic effects blood glucose↑↑ protein synthesis↑ fat breakdown for energy useIglucose utilization