Section 4 Regulation of the heartOutlineNervousRegulation.Humoral Regulation·Autoregulation
Outline • Nervous Regulation • Humoral Regulation • Autoregulation Section 4 Regulation of the heart
VasomototcenterBioodvesselsNervous RegulationSympatheticchainVagusHeartVasoconstrictorCardioinhibitorVasodiatorBloadvessels
Nervous Regulation
Innervation of cardiovascular systemIXafferentCarotidMedullarysinusesXafferentcardiovascularcentreVagalmotor neurdronQo0o0006c00ecocOAorticbaroreceptoraSympathetic efferentoT,TnAcetylcholinenterneuronVesselSinusmuscarinicnodeStellateganglion,cervicalsympatheticgangliaNoradrenalineβAdrenaline inbloodAcetylcholinetransmitterSympatheticstimulationincreases contractilityfrequency,conductionvelocity,andirritability
Innervation of cardiovascular system Stellate ganglion ， cervical sympathetic ganglia
Nervous regulation of the circulationHeartBlood VesselVasoconstrictionIntropyNE!NEVasoconstrictionNEOLChronotropyMPVasodilationDromotropyVasodilationSympatheticMNerve TerminalAChParasympatheticSympathetic CholinergicNerve TeriminalNerveTerminal
Nervous regulation of the circulation
Mechanisms of norepinephrine- increased Na+ & Ca2+ permeability If ↑ , phase 4 spontaneous depolarizationf:Autorhythmicity ↑· Ca2+ influx ↑ , phase 0 amplitude & velocity ↑Conductivity ↑·Ca2+ influx , Ca2+ release ↑, [Ca2+ Ji ↑,Contractility个
— increased Na+ & Ca2+ permeability • If ↑, phase 4 spontaneous depolarization↑, Autorhythmicity ↑ Mechanisms of norepinephrine • Ca2+ influx ↑, Ca2+ release ↑, [Ca2+ ] i ↑, Contractility ↑ • Ca2+ influx ↑, phase 0 amplitude & velocity ↑, Conductivity ↑