WELCOMETOHumanPhysiology(LECTURESESSION)Department of PhysiologyYangzhou University School of MedicineSpring2020
WELCOME TO Human Physiology (LECTURE SESSION) Department of Physiology Yangzhou University School of Medicine Spring 2020
Living Organism Comes froma Single Cell:Fertilized EggBlastocystTotipotentMorulaOocyteHumanFetusSpermPluripotentInnerMassCellsfEmbtyonie Stem Ce小Examples:福ImmuneSystemCirculatorySystemNervousSystemUnipotent
Living Organism Comes from a Single Cell: Fertilized Egg
Stem Cell BiologyNationality JapaneseFieldsstemcell research1]12][3]InstitutionsKyotoUniversityGladstoneInstituteofCardiovascularDiseaseAlmaKobeUniversitymaterOsaka CityUniversityGladstone Institute ofJamesThomsonandShinyaYamanakaCardiovascularDiseaseKnownforInducedPluripotentStemCellNotableRobertKochPrize(2008)awardsShawPrize(2008)JamesAlexanderThomson(bornDecemberGairdner Foundation20,1958)isanAmericandevelopmentalIntermationalAward(2009)AlbertLaskerBasicMedicalbiologistbestknownforderivingthefirstResearchAward(2009)humanembryonicstem(ES)celllinein1998BBVAFoundationFrontiersofKnowledgeAward(2010)[1] andforderivinghuman induced pluripotentWolfPrize(2011)stem(iPS)cells in2007.[2]FellowoftheNationalAcademyofSciences/4)(2012)MillenniumTechnologyPrize(2012)
Stem Cell Biology
EmbryonicStemCellsvsInducedPluripotentStemCellsFertilizedeggSkinfibroblasts,etc.IsolatedandculturedDifferentiationBlastocystinductionIntroductionofparticulargenesand cell cultureEScellsiPScellsHematopoieticstemcellsErythrocyteErythrocyteprecursor line can becul-precursorlineturedandpropa-gated in vitro nearlypermanentlyErythrocytesEnucleationEnucleatedmatureerythrocytes
Embryonic Stem Cells vs Induced Pluripotent Stem Cells
ProductionofmiceusingiPScellsandtetraploidcomplementationXiao-YangZhao'4,ZhuoLvl4,WeiLil4,FanyiZeng&QiZhou'StateKeyLaboratoryofReproductiveBiologyInstituteofZoology,ChineseAcademyfSciences,Beijing,China.InstituteofMedicalGenetics,Shanghai JiaoTongUniversity,Shanghai,China.nstituteofMedicalScience,ShanghaiJiaoTongUniversityShanghai,China.GraduateSchoolofChinseAcademyofSciences,BeijinChina.Correspondence shouldbeaddressedtoQ.Z.(qzhou@ioz.ac.cn)andF.Z.(fzeng@sjtu.edu.cn)