Definition Diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia due to defective insulin secretion or insulin action or both
Definition Diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia due to defective insulin secretion or insulin action or both
Epidemiology of diabetes 32.9 24% 84.5 17.5 132.3 23% 57% 14.1 50% 44% World 1.0 2000: 151 rnillion 1.3 2010:221 million 33 n 46%
Epidemiology of diabetes
Location( Age<15yo) TIDM incidence(1/100000 Finland 34 14.6 Australia 14.4 Indonesia 2.53 Singapore 2.4 South Korea 186 New Zealand 1/1000 Japan 23(88-92yr) Hang Kong 125 Tai wan 1.5(<20y) Beijing 0.94 Shanghai 083 luNy 0.12 Guilin 0.30 Huhehaote 0.91 Nanjing 0.69 Hainan 20
Location（Age<15yo） T1DM incidence (1/100000) Finland 34 U.S.A . 14.6 Australia 14.4 Indonesia 2.53 Singapore 2.4 South Korea 1.86 New Zealand 1/1000 Japan 2.53（88－92yr） Hang Kong 1.25 Tai Wan 1.5（< 20y ) Beijing 0.94 Shanghai 0.83 Zuiyi 0.12 Guilin 0.30 Huhehaote 0.91 Nanjing 0.69 Hainan 0.29
Classification of dia betes mellitus I. Type I diabetes(B-cell destruction, usuall leading to absolute insulin deficiency) A Immune mediated TIa B Idiopathic TIB II. Type 2 diabetes American Diabetes Association, 2004 To be continued
I. Type 1 diabetes (-cell destruction, usually leading to absolute insulin deficiency) A. Immune mediated T1A B. Idiopathic T1B II. Type 2 diabetes American Diabetes Association, 2004 Classification of diabetes mellitus To be continued
Classification of diabetes mellitus IlL. Other specific types A. Genetic defects of B-cell function 1. modY 3: Chromosome 12 HNF-1a 2. MODY 2: Chromosome 7, glucokinase 3. MODY 1: Chromosome 20 HNF-4a 4. MODY4: Chromosome 13. insulin promoter factor-1(IPF-1) 5. MODY5: Chromosome 17, HNF-I B 6. MoDY6: Chromosome 2. NeuroD 1 7. Mitochondrial dna 8. Others To be continued
Classification of diabetes mellitus III. Other specific types A. Genetic defects of -cell function 1. MODY 3 : Chromosome 12, HNF-1 2. MODY 2 : Chromosome 7, glucokinase 3. MODY 1 : Chromosome 20, HNF-4 4. MODY4 : Chromosome 13, insulin promoter factor-1 (IPF-1) 5. MODY5: Chromosome 17, HNF-1 6. MODY6 : Chromosome 2, NeuroD1 7. Mitochondrial DNA 8. Others To be continued