Teaching plan of Soochow University Subjects:BIOCHEMISTRY Class:2019 Pharmaceutical Sciences Date:2020/10/21/Wed/5-7 Teaching duration: chapter 6 Text page:183-234 150min Title Enzymes Teaching 1.Understand the kinetics of enzyme-catalyzed reaction; goal 2.Make the students understand the regulation of enzyme activity. Teaching content and time distribution Section 2 ENZYME KINETICS 50 min 2.5 Enzyme Can Be Inhibited by Specific Substances 50min Reversible enzyme inhibitor:Competitive inhibitor (20 min),noncompetitive inhibitor(10 min),uncompetitive inhibitor(10 min);Irreversible inhibitor(10 min) Section 3 REGULATION OF ENZYMES 50 min Teaching 3.1 Allosteric Enzyme Can Be Regulated by Altering Their Conformations 15min content、 3.2 Enzyme Activity Can Be Regulated by Chemical Modification 15 min 3.3 Many Enzymes Are Released as Inactive Precursors 20 min Teaching Zymogen,and activation of zymogen,the significance of zymogen method、 Section 4 Medical aspects of enzymes 50 min Teaching 4.1 Deficiency or Abnormality of Enzymes Can Cause Diseases 20min emphasis、 4.2 Serum Enzymes Are Used for the Diagnosis of Many Diseases 20 min difficulty、 4.3 Enzymes Are Used as Chemical Reagents in Clinical Analyzers 10 min time Teaching emphasis:Kinetics of enzyme-catalyzed reaction;Michaelis-Menten distribution equation;The factors that affect the enzymatic reaction.Optimum T,pH.Vman, Km.Regulation of enzyme activity.The activation of zymogen. Teaching difficulty:The kinetic parameter change of different types of reversible enzyme inhibitors.The difference between the allosteric regulation and chemical modification of enzyme. Teaching method:Mainly teaching method,in auxiliary the heuristic teaching method on appropriate time. Teaching Multimedia Teaching combine with PPT and viedo instrument
Teaching plan of Soochow University Subjects：BIOCHEMISTRY Class：2019 Pharmaceutical Sciences Date：2020/10/21/Wed/5-7 chapter 6 Text page： 183-234 Teaching duration: 150min Title Enzymes Teaching goal 1. Understand the kinetics of enzyme-catalyzed reaction; 2. Make the students understand the regulation of enzyme activity. Teaching content、 Teaching method、 Teaching emphasis、 difficulty、 time distribution Teaching content and time distribution Section 2 ENZYME KINETICS 50 min 2.5 Enzyme Can Be Inhibited by Specific Substances 50 min Reversible enzyme inhibitor: Competitive inhibitor (20 min), noncompetitive inhibitor (10 min), uncompetitive inhibitor (10 min); Irreversible inhibitor (10 min) Section 3 REGULATION OF ENZYMES 50 min 3.1 Allosteric Enzyme Can Be Regulated by Altering Their Conformations 15min 3.2 Enzyme Activity Can Be Regulated by Chemical Modification 15 min 3.3 Many Enzymes Are Released as Inactive Precursors 20 min Zymogen, and activation of zymogen, the significance of zymogen Section 4 Medical aspects of enzymes 50 min 4.1 Deficiency or Abnormality of Enzymes Can Cause Diseases 20 min 4.2 Serum Enzymes Are Used for the Diagnosis of Many Diseases 20 min 4.3 Enzymes Are Used as Chemical Reagents in Clinical Analyzers 10 min Teaching emphasis: Kinetics of enzyme-catalyzed reaction;Michaelis-Menten equation; The factors that affect the enzymatic reaction. Optimum T, pH. Vman, Km. Regulation of enzyme activity. The activation of zymogen. Teaching difficulty: The kinetic parameter change of different types of reversible enzyme inhibitors. The difference between the allosteric regulation and chemical modification of enzyme. Teaching method: Mainly teaching method, in auxiliary the heuristic teaching method on appropriate time. Teaching instrument Multimedia Teaching combine with PPT and viedo
Question 1.Three modes of reversible enzyme inhibitors. and quiz in 2.What're the zymogen and the activation of zymogen? class 3.Clinical application of enzymes. After class The difference between allosteric regulation and chemical modification of enzyme summary is most difficult for students to understand
Question and quiz in class 1. Three modes of reversible enzyme inhibitors. 2. What’re the zymogen and the activation of zymogen? 3. Clinical application of enzymes. After class summary The difference between allosteric regulation and chemical modification of enzyme is most difficult for students to understand