The biological effects of IL-2NK cellsActivatedTh-IL-2BcellsT cellsNK cellsMdProliferationActivationEnhancesProliferation(LymphokicytotoxicIg expressionLymphokinene-activatedactivities andsecretionkiller (LAK)CKssecretion
IL-2 ActivatedTh NK cells B cells T cells NK cells MΦ Proliferation Ig expression Proliferation Lymphokine secretion Activation （Lymphoki ne-activated killer (LAK） Enhances cytotoxic activities and CKs secretion The biological effects of IL-2
I Naming and Classification2.干扰素（Interferons，IFNs）最早发现的细胞因子，因具有干扰病毒复制的功能而得名。白细胞合成Type IIFN-αIFN-β成纤维细胞合成Type II活化T细胞合成IFN-生物学活性：*抗病毒抗肿瘤*调节免疫应答
2. 干扰素（Interferons，IFNs） 最早发现的细胞因子，因具有干扰病 毒复制的功能而得名。 TypeⅠ IFN-α 白细胞合成 IFN-β 成纤维细胞合成 TypeⅡ IFN-γ 活化T细胞合成 Ⅲ Naming and Classification 生物学活性: *抗病毒 *抗肿瘤 *调节免疫应答
IFNs and Their BioactivitiesProducerFunctionCytokineTargetviralreplicationIFN-αleukocytesvariousMHCIexpressionviralreplicationIFN-βfibroblastsvariousMHCIexpressionvariousViral replicationMpMHC expressionIFN-Th1,Tc, NKactivatedBIgclassswitchtoIgGTh2 cellsproliferationMopathogeneliminationItalicized activities are inhibited
IFNs and Their Bioactivities Cytokine Producer Target Function IFN-a leukocytes various viral replication MHC I expression IFN- fibroblasts various viral replication MHC I expression IFN-g Th1,Tc , NK various Viral replication Mφ MHC expression activated B Ig class switch to IgG Th2 cells proliferation Mφ pathogen elimination Italicized activities are inhibited
The role of IFN-α against virusVirusRestrainreplicationreplicationOIFN-inducedCproteinsstimulatingSignaltransfernuclearnuclearIFN-α
The role of IFN-a against virus Virus replication Restrain replication Signal transfer IFN-a IFN-induced proteins stimulating nuclear nuclea r
I Naming and Classification3.肿瘤坏死因子超家族（TNFSF）Tumor necrosis factor superfamily肿瘤坏环死因子因最初发现可引起肿瘤组织环死而得名。自前已发现30余种细胞因子*TNF-a：主要由Mo/M细胞合成*TNF-β：又称淋巴毒素(lymphotoxin，LT)主要由活化T细胞合成其它：FAS-FASL;CD40-CD40L等
肿瘤坏死因子因最初发现可引起肿瘤组织 坏死而得名。目前已发现30余种细胞因子。 *TNF-α: 主要由Mo/Mφ细胞合成 *TNF-β: 又称淋巴毒素(lymphotoxin, LT) 主要由活化T细胞合成 其它：FAS-FASL;CD40-CD40L等。 3. 肿瘤坏死因子超家族（TNFSF） Tumor necrosis factor superfamily Ⅲ Naming and Classification