Section 2 Biosynthesis of purine and pyrimidine
Section 2 Biosynthesis of purine and pyrimidine
Overview of dietary nucleotide metabolism Dietary nucleoprotein Gastric acid protein← >Nuclei acid (RNA or DNA) (deoxy)ribonuclease from pancreas nucleotide Nucleotidase from intestinal 曾章 endothelium nucleoside phosphate nucleoside phosphorylase from g本 intestinal endothelium Uric acid<…base >(deoxy)ribose inside intestinal endothelium
Overview of dietary nucleotide metabolism Dietary nucleoprotein protein Nuclei acid（RNA or DNA） Gastric acid nucleotide (deoxy)ribonuclease from pancreas nucleoside phosphate Nucleotidase from intestinal endothelium base (deoxy)ribose nucleoside phosphorylase from intestinal endothelium inside intestinal endothelium Uric acid
We do not need to eat purines and pyrimidines in our diet because we have ways to make them. Our body has two ways of making purine and pyrimidine nucleotides:De novo synthesis and the salvage pathway. New or recycled.We recycle more than we make new
We do not need to eat purines and pyrimidines in our diet because we have ways to make them. Our body has two ways of making purine and pyrimidine nucleotides: De novo synthesis and the salvage pathway. New or recycled. We recycle more than we make new
1.De novo synthesis of purine nucleotide
1. De novo synthesis of purine nucleotide
.Source of nitrogen and carbon atoms of the purine ring C02 glycine Aspartate→ N5.N10methenyl- Ni0 formyl tetrahydrofolate tetrahydrofolate glutamine (amide nitrogen)
•Source of nitrogen and carbon atoms of the purine ring CO2 Aspartate N10 formyl - tetrahydrofolate glycine N5,N10methenyltetrahydrofolate glutamine （amide nitrogen）