Learning objectives At the end of this lecture the students should be able to 1. Outline the distinguishing features of influenza viruses 2. Outline the basic steps in the pathogenesis of influenza. 3. Discuss the potential complications of influenza infection. Understand why a"flu" shot is needed every year. 5. Understand how genome structure and viral polymerase impact on appearance of new virus strains. 6. Outline the impact of animal reservoirs of viruses in the recurrence of II niluenza. Reference: Jawetz, Melnick, Adelberg's Medical Microbiology, 25t Influenza virus-an example of virus mutations. key notes on medical molecular virology Editors: Yu-mei Wen, et al. Fudan University Press, p64-75, 2005
Learning Objectives At the end of this lecture, the students should be able to: 1. O tli th di ti i hi f t f i fl i O utline the di stinguishing fea tures o f influenza viruses. 2. Outline the basic steps in the pathogenesis of influenza. 3. Discuss the potential complications of influenza infection. 4 Understand 4. Understand why a “flu ” shot is needed every year shot is needed every year. 5. Understand how genome structure and viral polymerase impact on appearance of new virus strains appearance of new virus strains. 6. Outline the impact of animal reservoirs of viruses in the recurrence of influenza. Reference: Jawetz, Melnick, & Adelber g's Medical Microbiology, 25t Influenza virus-an example of virus mutations. key notes on medical molecular virology. Editors: Yu-mei Wen, et al. Fudan University Press, p64-75, 2005
Respiratory viruses 1 Orthomyxovirus (idae) influenza v influ B 2 Paramyxoviruses(idae vaccine measles mumps RSV(respiratory syncytial V) MMR 3 others measles- mu Togaviridae: Rubella v rubella Coronaviridae: SARS-CoV vaccine Others: adenovirus, rhinovirus(Piconaviridae)
Respiratory viruses 1 Orthom yxovirus (~idae ) ： influenza V 2 Paramyxoviruses (~idae) ： influ B vaccine measles mumps RSV (respiratory syncytial V) 3 others i id b ll MMR, measlesmumps - Togav i ridae: Rub ella V Coronaviridae: SARS-CoV Oth d i hi i (Pi i id ) mumps rubella vaccine Others: a denov irus, rhinov irus (Piconav i ridae )…
Part I: Orthomyxovirus Influ v orthomyxoviridae并 Ortho,“ standard, correct;”myxo,“ mucus Pathogen causing viral influenza 3 subtypeS (ABC) Influenza a leads pandemic/epidemic pandemic/epidemic 1st finding: in 1933, by a british doctor wilson Smith, named HIN1
Part I: Orthomyxovirus -- Influ V • orthomyxoviridae ＃ Ortho, “standard, correct;” myxo, “mucus” • Pathogen causing viral influenza Pathogen causing viral influenza • 3 subtypes（ABC） • I fl A l d d i / id i Influenza A leads pandemic/epidemic • pandemic/epidemic ＃ t • 1s finding: in 1933, by a British Doctor Wilson Smith，named H1N1
Influenza Tvpes ype A Epidemics and pandemics Animals and humans All ages Type b Milder epidemics Humans only Primarily affects children
Influenza Types • Type A – Epidemics and pandemics – Animals and humans – All ages • T Bype B – Milder epidemics – H l umans on l y – Primarily affects children
1. Properties of influ SS RNA, envelope core: RNA(7-8, segmented) nucleoprotein (NP,A,B, C, category RNA polymerase Matix protein Hemagglutinin, HA#, 15 envelope Neuraminidase. na#. 9
1. Properties of influ v • -ss RNA, envelope core ：RNA （ 7 ～ 8 ， segmented）、 nucleoprotein （NP, A ， B ，C, category）、 RNA polymerase Matix protein Matix protein Hemagglutinin, HA #,15 envelope Neuraminidase, NA #, 9