脑室旁白质软化PVLperiventricular leukomalacia,PHILIPPHILIPSDEPART.PEDIATRIC.IST.HOSP.B.M.U.RenaDEPART PEDIATRIC.IST.HOSP.B.M.U.ABD15:58:1813:34:7518HBERTRB脑室旁白质软化A病变早期双侧脑室旁强回声强度与脉络丛等同B病变晚期原强回声区域形成大小不等多灶囊腔
脑室旁白质软化 pe rivent ricula r leukoma la cia, PVL
Cerebralbloodflow(CBF)：2. Non-compensation : ganglion.brainstem damageBasal gangliacerebellumbrainstemSuddenly &completelyasphyxia
Basal ganglia brainstem ce r ebe llum S uddenly & comple t e ly asphyxia 2. Non-compensation：ganglionbrainstem damage Cerebral blood flow (CBF)：
Cerebral blood flow (CBF):3. autoregulation ↓ -→Pressure-passivecerebral circulation(PPCC)PPCCBrain edemaCBFcerebral hemorrhageHIECerebral ischemia,BP
3. autoregulation ↓→Pressure-passive cerebral circulation (PPCC) Brain edema cerebral hemorrhage Cer ebr al is chemia, HI E BP CBF PPCC Cerebral blood flow (CBF)：
Change of brain metabolism:1.oxygen free rsadical→rupture of cell membranedestroyBBB(1)over production : cytochrome-oxydase+ ;reperfusion:xanthine oxidase ↑urea+oxyradicalshypoxanthine-（2）removenotenough：超氧化物歧化酶(SOD)
Change of brain metabolism: 1.oxygen fr e e rsadical→rupture of cell membrane destroy BBB (1) over production： cytochrome-oxydase↓； reperfusion：xanthine oxidase↑ hypoxant hi ne -→ urea +oxyradicals (2) remove not enough：超氧化物歧化酶 （SOD）↓
Change of brain metabolism:2.imbalance of Na &Ca :anaerobic glycolysis-→>lactic acid ↑ ,ATP →pump out of order -> Ca++inflow→chaos ofsignal→Na++inflow-intra-cellularedema3.excitable neurotransmitter:glutamic acid ;β-opioid peptide
Change of brain metabolism: 2.imbalance of Na &Ca： anaerobic glycolysis→lactic acid↑,ATP↓→ pump out of order → Ca++ inflow→chaos of signal →Na++ inflow→intra-cellular edema 3.excitable neurotransmitter: glutamic acid； β-opioid peptide