Natural penicillins ·Penicillin G ·Pharmacokinetics: Easily destroyed by gastric acid Wide distribution and 5%across BBB when in meningitis Renal tubular excretion in prototype
Natural penicillins • Penicillin G • Pharmacokinetics: Easily destroyed by gastric acid Wide distribution and 5% across BBB when in meningitis Renal tubular excretion in prototype
Penicillin G HC CH OH 111H N Thiazolidine Acyl side-chain ring H-11I B-lactam ring H O H Thiazolidine:噻唑烷；acy小：酰基
Thiazolidine: 噻唑烷； acyl: 酰基
A Afferent arteriole Bowman's capsule Efferent arteriole Parietal wall Bowman's capsule Visceral wall podocytes. Distal convoluted tubule B Glomerular capillaries (fenestrated endothellum) Collecting tubule Proximal tubule (convoluted and -Collecting duct straight portions) CORTEX MEDULLA Loop of Henle Thick ascending limb◆ Papillary duct Loop of Henle Thin segments Note:The renal corpuscle is Bowman's capsule (A) and the glomerulus(B) The nephron and collecting duct system of the kidney
Antibacterial spectrum G+cocci:Staphylococcus infections G cocci:Staphylococcus pneumoniae infection √G*bacilli:diphtheria(白喉)，tetanus (破伤风) √Leptospira(螺旋体)：leptospirosis(钩 端螺旋体病 ) √Actinomycetes(放线菌)： actinomycosis(放线菌病)
Antibacterial spectrum G+ cocci : Staphylococcus infections G- cocci: Staphylococcus pneumoniae infection G+ bacilli: diphtheria（白喉），tetanus （破伤风） Leptospira（螺旋体）: leptospirosis（钩 端螺旋体病） Actinomycetes（放线菌）： actinomycosis（放线菌病）
Neisseria gonorrhoeae 淋病奈瑟菌
淋病奈瑟菌