Antiestrogens (1)Effects: Partial agonist/antagonist for estrogen receptor (2)Uses: anovulatory infertility(无排卵性不孕) · menstrual disorders advanced breast cancer functional amenorrhea(功能性闭经 amenorrhea galactorrhea syndrome(闭经溢乳综合征) (3 )Adverse effects Multiple ovulation with multiple pregnancy(3 Ha) ovary tumefaction(卵巢肿大) ovarian carcinoma following multiple exposure
(2) Uses: • anovulatory infertility (无排卵性不孕) • menstrual disorders • advanced breast cancer • functional amenorrhea (功能性闭经) • amenorrhea galactorrhea syndrome (闭经溢乳综合征) (3) Adverse effects: • Multipleovulation with multiple pregnancy (多胎) • ovary tumefaction (卵巢肿大) • ovarian carcinoma following multiple exposure. (1) Effects: Partial agonist/antagonistfor estrogen receptor Antiestrogens
Antiestrogens Tamoxifen 苯氧胺(他莫昔芬) OCH2 CH2N (1)Nonsteroid competitive estrogen antagonist C=C (2)Used for treatment of estrogen dependent CH2CH3 breast cancer T amoxien
(1) A nonsteroid competitive estrogen antagonist (2) Used for treatment of estrogen dependent breast cancer Tamoxifen 三苯氧胺（他莫昔芬） Antiestrogens