2) Microscopy in which the particles are sized through the use of a calibrated grid background or other measuring device (range 02~100m)
2) Microscopy in which the particles are sized through the use of a calibrated grid background or other measuring device. (range 0.2100m)
3)Sedimentation rate in which particle size is determined by measuring the terminal settling velocity of particles through a liquid medium in a gravitational or centrifugal environment (range: 0. 8-300microns) 4)Light energy diffraction or light scattering In which particle size is determined by the reduction in light reaching the sensor as the particle, dispersed in a liquid or gas, passes through the sensing zone (range 0.2.500 microns)
3) Sedimentation rate in which particle size is determined by measuring the terminal settling velocity of particles through a liquid medium in a gravitational or centrifugal environment.(range:0.8-300microns) 4) Light energy diffraction or light scattering In which particle size is determined by the reduction in light reaching the sensor as the particle, dispersed in a liquid or gas, passes through the sensing zone (range 0.2500 microns)
5) Laser holography(激光全息照相术) In which a pulsed laser is fired through an aerosolized particle spray and photographed in three dimensions with a holographic camera, allowing the particles to be individually imaged and sized (range: 1.4-100micros 用一束激光通过雾化粒子流,用全息照相术 拍三维照片,观察到粒子的形态和大小
5) Laser holography （激光全息照相术） In which a pulsed laser is fired through an aerosolized particle spray and photographed in three dimensions with a holographic camera, allowing the particles to be individually imaged and sized (range:1.4100micros). 用一束激光通过雾化粒子流，用全息照相术 拍三维照片，观察到粒子的形态和大小
6) Cascade impaction(阶式碰撞) is based on the principle that a particle, driven by an airstream, will impact on a surface in its path, provided that its inertia(惯性) is sufficient to overcome the drag force that tends to keep it in the airstream 当粒子用空气流输送时会撞击到一表面,假 定其惯性大于其向内的拉力,粒子流则会在 不同速率的空气流驱动下按不同的粒径分离
6) Cascade impaction （阶式碰撞） is based on the principle that a particle, driven by an airstream, will impact on a surface in its path, provided that its inertia （惯性） is sufficient to overcome the drag force that tends to keep it in the airstream. 当粒子用空气流输送时会撞击到一表面，假 定其惯性大于其向内的拉力，粒子流则会在 不同速率的空气流驱动下按不同的粒径分离
Micromeritics(粉体学) Micromeritics is the science of small particles a It is important to study particles because the majority of drug dosage forms are solids a Solids are not"static" systems-the physical state of particles can be altered by physical manipulation and particle characteristics can alter therapeutic effectiveness
Micromeritics （粉体学） ◼ Micromeritics is the science of small particles. ◼ It is important to study particles because the majority of drug dosage forms are solids. ◼ Solids are not “static” systems-the physical state of particles can be altered by physical manipulation and particle characteristics can alter therapeutic effectiveness