Medicinal chemistry Chapter 1 Introduction College of Pharmacy, SDU
Medicinal Chemistry Chapter 1 Introduction College of Pharmacy, SDU
Definition Medicinal chemistry is a chemistry-based discipline, involving aspects of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships ( sARs)
Definition • Medicinal chemistry is a chemistry-based discipline, involving aspects of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships (SARs)
In particular, Medicina/ chemistry also involves the discovery of new chemical entities for the treatment of diseases and the systematic study of the structure-activity relationships of the active compounds. Such studies provide the basis for development of better medicinal agents from lead compounds found via random screening, systematic screening and rational design
• In particular, Medicinal chemistry also involves the discovery of new chemical entities for the treatment of diseases and the systematic study of the structure-activity relationships of the active compounds. Such studies provide the basis for development of better medicinal agents from lead compounds found via random screening, systematic screening and rational design
Drug is any substance presented for treating curing or preventing disease in human beings or in animals. It may also be used for making a medical diagnosis or for restoring, correcting or modifying physiological functions
• Drug is any substance presented for treating, curing or preventing disease in human beings or in animals. It may also be used for making a medical diagnosis or for restoring, correcting, or modifying physiological functions
Structure-activity relationship (saR)is the relationship between chemical structure and pharmacological activity for a series of compounds Lead compound is a compound that has a desirable biological activity with therapeutic relevance, but typically has some shortcoming that is likely to be overcome through the development of analogs
• Structure-activity relationship (SAR) is the relationship between chemical structure and pharmacological activity for a series of compounds. • Lead compound is a compound that has a desirable biological activity with therapeutic relevance, but typically has some shortcoming that is likely to be overcome through the development of analogs