Fine (or a No 80) powder-All particles pass through a No. 80 sieve. There is no limit as to greater fineness. Very fine (or a No. 120) powder-All particles pass through a No. 120 sieve There is no limit as to greater fineness
◼ Fine (or a No 80) powder-All particles pass through a No. 80 sieve. There is no limit as to greater fineness. ◼ Very fine (or a No. 120) powder-All particles pass through a No. 120 sieve. There is no limit as to greater fineness
Granules typically fall within the range of 4(4.75 mm) to 12-sieve size, although granulations of powders prepared in the 12-to 20-sieve(850 um)range are sometimes used in tablet making The purpose of particle size analysis in pharmacy is to obtain quantitative data on the size, distribution, and shapes of drug and nondrug components to be used in pharmaceutical formulations
◼ Granules typically fall within the range of 4（4.75 mm) to 12-sieve size, although granulations of powders prepared in the 12- to 20-sieve (850 m) range are sometimes used in tablet making. ◼ The purpose of particle size analysis in pharmacy is to obtain quantitative data on the size, distribution, and shapes of drug and nondrug components to be used in pharmaceutical formulations
Particle size can influence a variety of important factors, including the following: 1) Dissolution rate of particles intended to dissolve; drug micronization can increase the rate of drug dissolution and its bioavailability 2) Suspendability of particles intended to remain undissolved but uniformly dispersed in a liquid vehicle(e.g, fine dispersions have particles approximately 05-10m)
Particle size can influence a variety of important factors, including the following: 1) Dissolution rate of particles intended to dissolve; drug micronization can increase the rate of drug dissolution and its bioavailability. 2) Suspendability of particles intended to remain undissolved but uniformly dispersed in a liquid vehicle (e.g., fine dispersions have particles approximately 0.5-10 m)
3)Uniform distribution of a drug substance in a powder mixture or solid dosage form to ensure dose-to-dose content uniformity 4)Penetrability of particles intended to be inhaled for deposition deep in the respiratory tract (e.g, 1-5 um) 5)Lack of grittiness of solid particles in dermal ointments, creams, and ophthalmic preparations(e.g, fine powders may be 50-100 um in size)
3) Uniform distribution of a drug substance in a powder mixture or solid dosage form to ensure dose-to-dose content uniformity. 4) Penetrability of particles intended to be inhaled for deposition deep in the respiratory tract (e.g., 1-5 m). 5) Lack of grittiness of solid particles in dermal ointments, creams, and ophthalmic preparations (e.g., fine powders may be 50-100 m in size)
a number of methods exist for the determination of particle size 1) Sieving Particles are passed by mechanical shaking through a series of sieves of known and successively smaller size and the determination of the proportion of powder passing through or being withheld on each sieve(range about 40-9500um, depending upon sieve sizes)
A number of methods exist for the determination of particle size 1) Sieving Particles are passed by mechanical shaking through a series of sieves of known and successively smaller size and the determination of the proportion of powder passing through or being withheld on each sieve (range about 40-9500m, depending upon sieve sizes)