4. Dosage Form Design: Biopharmaceutic and Pharmacokinetic considerations
4. Dosage Form Design: Biopharmaceutic and Pharmacokinetic Considerations
Contents General principles of drug absorption Il. Dissolution and drug absorption III. Bioavailability and bioequivalence Iv. Routes of drug administration V. Fate of drug after absorption VI. Pharmacokinetic principles
Contents I. General principles of drug absorption II. Dissolution and drug absorption III. Bioavailability and bioequivalence IV. Routes of drug administration V. Fate of drug after absorption VI. Pharmacokinetic principles
Biopharmaceutics is the area of study embracing the relationship between the physical, chemical, and biological sciences as they apply to drugs, dosage forms, and to drug action. (生物药剂学是围绕物理学、化学和生物科 学及它们关于药物、剂型和药物作用相互 关系的研究领域。)
Biopharmaceutics is the area of study embracing the relationship between the physical, chemical, and biological sciences as they apply to drugs, dosage forms, and to drug action. （生物药剂学是围绕物理学、化学和生物科 学及它们关于药物、剂型和药物作用相互 关系的研究领域。）
For a drug to exert its biological effect, it must be transported by the body fluids, traverse the required biological membrane barriers, escape widespread distribution to unwanted areas, endure metabolic attack,(经受代谢改变) penetrate in adequate concentration to the sites of action, a interact in a specific fashion a causing an alteration of cellular function
For a drug to exert its biological effect, it must be ◼ transported by the body fluids, ◼ traverse the required biological membrane barriers, ◼ escape widespread distribution to unwanted areas, ◼ endure metabolic attack, （经受代谢改变） ◼ penetrate in adequate concentration to the sites of action, ◼ interact in a specific fashion, ◼ causing an alteration of cellular function
Oral administration Gastrointestinal tract Dru Intravenous injection Circulatory systems D 會又 Intramuscular injection Tissues Metabolic sites Drug Subcutaneous injection metabolites ious roule schematic representation of events of absorption, metabolism, and excretion of drugs after their administration by var