Hepatitis Avirus Transmission o Virus can be transmitted via fecal-oral route ingestion of contaminated food and water can cause infection HAV in shellfish is from sewage-contaminated water Virus can be transmitted by food handlers, day care workers. and children
Hepatitis A Virus Transmission Virus can be transmitted via fecal-oral route ingestion of contaminated food and water can cause infection HAV in shellfish is from sewage-contaminated water Virus can be transmitted by food handlers, daycare workers, and children
Concentration of Hepatitis A Virus in various Body Fluids F eces Serum Saliva Urine 10 10 10 108 1010 Infectious Doses per ml Source: Viral Hepatitis and Liver Disease 1984 9-22 J Infect dis1989;160:887-890
Concentration of Hepatitis A Virus in Various Body Fluids Source: Viral Hepatitis and Liver Disease 1984;9-22 J Infect Dis 1989;160:887-890 Feces Serum Saliva Urine Body Fluid Infectious Doses per ml 100 102 104 106 108 1010
Geographic Distribution of HAV Infection Anti-HAV Prevalence High Intermediate LOW 口 Very Low
Geographic Distribution of HAV Infection Anti-HAV Prevalence High Intermediate Low Very Low
Age-specific Mortality Due to Hepatitis A Age group Case-Fatality (years) (per1000) 3.0 5-14 1.6 15-29 1.6 30-49 3.8 >49 17.5 Total 4、1 Source: Viral Hepatitis Surveillance Program, 1983-1989
Age-specific Mortality Due to Hepatitis A Age group (years) Case-Fatality (per 1000) <5 3.0 5-14 1.6 15-29 1.6 30-49 3.8 >49 17.5 Total 4.1 Source: Viral Hepatitis Surveillance Program, 1983-1989
Hepatitis A-Clinical Features Average 30 days Incubation period Range 15-50 days Jaundice by y 109 age group 6-14yi 409-50% >14 yrs 70%-80%
Hepatitis A - Clinical Features Incubation period Average 30 days Range 15-50 days Jaundice by age group <6 yrs <10% 6-14 yrs 40%-50% >14 yrs 70%-80%