Prion
Prion
Similar to Viruses Atypical Agents Small a Filterable Need host cells No machinery for energy generation of protein synthesis
Similar to Viruses Atypical Agents ▪ Small ▪ Filterable ▪ Need host cells ▪ No machinery for energy generation of protein synthesis
Different from viruses No detectable virions in infected tissues a No detectable virions in purified infectious material If nucleic acid is present, very small Very resistant
Different from viruses ▪ No dectectable virions in infected tissues ▪ No detectable virions in purified infectious material ▪ If nucleic acid is present, very small ▪ Very resistant
Resistant to or only Inactivated by partially inactivated 1 Autoclaving by 2. 5%sodium 1. Formaldehyde hypochlorite 2 Ethanol 3. Sodium hydroxide 3. Glutaraldehyde 4. Proteases, urea 4 Ultraviolet and other protein ionizing irradiation denaturants 5. Non-ionic detergents
▪ Resistant to or only partially inactivated by 1. Formaldehyde 2. Ethanol 3. Glutaraldehyde 4. Ultraviolet and ionizing irradiation 5. Non-ionic detergents ▪ Inactivated by 1. Autoclaving 2. 5%sodium hypochlorite 3. Sodium hydroxide 4. Proteases, urea, other protein denaturants
Pathogensis Kuru CUD(Creutzfeldt Jakob disease) GSS(Gerstmann Straussler-Scheinker syndrome) FFI(Fetal familial insomnia) Scrapie(sheep and goats) Bovine spongiform encephalopathy Transmissible mink encephalopathy Chronic wasting disease of mule deer
Pathogensis ▪ Kuru ▪ CJD(Creutzfeldt Jakob disease) ▪ GSS(Gerstmann Straussler-Scheinker syndrome) ▪ FFI(Fetal familial insomnia) ▪ Scrapie(sheep and goats) ▪ Bovine spongiform encephalopathy ▪ Transmissible mink encephalopathy ▪ Chronic wasting disease of mule deer