HepatitisA- Clinical features Milder disease than Hepatitis B o asymptomatic infections are very common, especially in children Adults, especially pregnant women, may develop more severe disease o no chronic form of the disease Complications Fulminant hepatitis is rare: 0.1%o of cases
Hepatitis A - Clinical Features Milder disease than Hepatitis B; asymptomatic infections are very common, especially in children. Adults, especially pregnant women, may develop more severe disease no chronic form of the disease. Complications: Fulminant hepatitis is rare: 0.1% of cases
Pathogenesis acquisition 露Be Stool
Pathogenesis
Pathogenesis of HAV HAV replicates slowly in the liver without producing apparent cytopathological effects (CEPS). In the absence of cytolysis, the virus readily establishes a persistent infection Jaundice, resulting from damage to the liver o antibody is detected and cell-mediated immune responses to the virus
Pathogenesis of HAV HAV replicates slowly in the liver without producing apparent cytopathological effects (CEPs). In the absence of cytolysis, the virus readily establishes a persistent infection. Jaundice, resulting from damage to the liver Antibody is detected and cell-mediated immune responses to the virus
For example An epidemic of HAv that occurred in Shanghai, China in 1988 in which 300,000 people were infected with the virus resulted from eating Anadara subcrenata obtained from a polluted river
For example An epidemic of HAV that occurred in Shanghai, China, in 1988 in which 300,000 people were infected with the virus resulted from eating Anadara subcrenata obtained from a polluted river
Time course of hav infection Icteric symptoms (if present) Elevated serum liver enzymes Incubation Prodro me Virus in blood Virus detectable in liver biopsy and feces HAV-specific IgG Virus in HAV-specific IgM eces 91o 12131 會 Week Ingestion
Time course of HAV infection