Structure Capsid e Small non ssRNA enveloped [7478 bases) icosahedral particle, 27 nm e 27nm in diameter ● SSRNA
Structure Small, nonenveloped icosahedral particle, 27 nm in diameter ssRNA
Replication o Unlike other picornaviruses, however, HAV is not cytolytic and is released by exocytosis Laboratory isolates of hav have been adapted to growth in primary and continuous monkey kidney cell lines, but clinical isolates are very difficult to grow in cell culture
Replication Unlike other picornaviruses, however, HAV is not cytolytic and is released by exocytosis. Laboratory isolates of HAV have been adapted to growth in primary and continuous monkey kidney cell lines, but clinical isolates are very difficult to grow in cell culture
Resistance Stable to: acid at ph 3 Solvents(ether, chloroform) detergents saltwatergroundwater(months) drying(stable) temperature 4C: weeks 56C for 30minutes: stable 61C for 20minutes: partial inactivation
Resistance Stable to: acid at pH 3 Solvents(ether,chloroform) detergents saltwater,groundwater(months) drying(stable) temperature 4℃: weeks 56℃for 30minutes: stable 61℃for 20minutes: partial inactivation
Resistance Inactivated by chlorine treatment of drinking water formalin(0.35%/, 37C, 72hours) acetic acid(2%0, 4hours) B-propiolactone丙内酯(0.25%1 hours Ultraviolet radiation(2p w/cm/min
Resistance Inactivated by: chlorine treatment of drinking water formalin(0.35%,37℃,72hours) acetic acid(2%,4hours) B-propiolactone丙内酯(0.25%,1hours) Ultraviolet radiation(2μW/㎝2 /min)