EBV infects EBV shed Transmission (oropharynx) Saliva) Differentiating EBV replicates Basal layer(CD21+) Persistent infection B Cell (CD21+)Lymph nodes Liver Blood EBv-infected b cells Spleen Activated T cells Polyclonal activation Atypical lymphocytes Immunoglobulin secrection Heterophile agglutinin Cytotoxicity Immunosuppression
Disease Cells infected Infectious mononucleosis B cell Nasopharyngeal epithelium Nasopharyngeal carcinoma Nasopharyngeal epithelium (especially in South-east Asia) (long latent period: 30+ years Burkitt's lymphoma Monoclonal B cell tumor (Endemic African form)(short latent period: 5+ years Immunoblastic lymphoma B lymphocytes (post-transplant/ AIDS Hodgkins diease Hodgkin Reed-Sternberg cells T cell lymphoma T cell lymphoma Oral hairy leucoplakia(AIDS) Epithelium along edge of tongue
Infectious mononucleosis Casusal: acute primary infection a Nasopharyngeal carcinoma 100% EBV-positive cells especially in South-east Asia) Cofactor(s)+ genetic risk Burkitt's lymphoma 100% EBV-positive Endemic African form) immunocompromised by malaria Immunoblastic lymphoma 70-100%EBV-positive cells (post-transplant/AlDS) Immunodeficiency genetic defect Hodgkin's disease 30-90% EBV-positive cells in subsets T cell lymphoma 30-100% EBV-positive cells in subsets Oral hairy leucoplakia(AIDS) EBV recurrence in immunodeficiency
EBNA Antibody EBV VCA lqG t EBV VCA laM Heterophile Agglutinin + Acute Recovery Later 2 3 Weeks Months Years
HERPESVIRUSES
HERPESVIRUSES