C. Antihypertensive Drugs 2. Clinicaluses (1)Hypertension single or combined with other drugs mild to moderate hypertension particularly useful in the treatment ofelderly patients, pure systolic hypertension, hypertension with heart failure (2)Other uses: diuretic, etc
2. Clinical uses (1) Hypertension single or combined with other drugs mild to moderate hypertension particularly useful in the treatment of elderly patients, pure systolic hypertension, hypertension with heart failure (2) Other uses: diuretic, etc. C. Antihypertensive Drugs
C. Antihypertensive Drugs 3. Adverse effects plasma levels of renin 1个 hypokalemia hy peruricema hyperglycemia hyperlipidemia
3. Adverse effects plasma levels of renin hypokalemia hyperuricemia hyperglycemia hyperlipidemia C. Antihypertensive Drugs
C. Antihypertensive Drugs Hemodynamic Effects of Long-Term Administration of Antihypertensive Agents HEART CARDIAC TOTAL PERIPHERAL PLASMA PLASMA RENIN RATE OUTPUT RESISTANCE VOLUME ACTIVITY Diuretics Sympatholytic agents Centrally acting Adrenergic neuron blockers a-Adrenergic antagonists B-Adrenergic antagonists No iSat ISA Arteriolar vasodilators Ca T-channel blockers ↓or↑↓or↑ ACE inhibitors ATRA tISA, intrinsic sympathomimetic activity. ACE, angiotensin converting enzyme. ATRA, angiotensin Il-receplor antagonist.unchanged " Changes are indicated as follows: t, increased; 4, decreased;-t, increased or no change;-+, decreased or no change;
C. Antihypertensive Drugs
C. Antihypertensive Drugs Calcium channel blockers Nifedipine硝苯地平 1. Pharmacologicaleffects D Relaxing vascular smooth muscles 2. Clinicaluses I Mild to severe hypertension(usually combined with B receptor blockers
Calcium channel blockers 1. Pharmacological effects Relaxing vascular smooth muscles 2. Clinical uses Mild to severe hypertension (usually combined with receptor blockers ) C. Antihypertensive Drugs Nifedipine 硝苯地平
C. Antihypertensive Drugs 3. Adverse effects Peripheral edema Reflex sympathetic activation Renin activity↑ Other calcium channel blockers amlodipine, etco
3. Adverse effects Peripheral edema Reflex sympathetic activation Renin activity Other calcium channel blockers: amlodipine, etc. C. Antihypertensive Drugs