(2) Nephrotoxicity: Conventional doses, infrequent toxicity; High doses, toxicity can be severe (3)Immunosuppression. (4) Hepatotoxicity
• (2) Nephrotoxicity: Conventional doses, infrequent toxicity; High doses, toxicity can be severe • (3) Immunosuppression. • (4) Hepatotoxicity
Clinical uses. Broad range. Well established: (1)Acute Lymphoblastic Leukemia of childhood.(2) Choriocarcinoma.(3)Cancers of breast, bladder, and head &e neck.(4)Useful in non-Hodgkin's lymphomas
• Clinical Uses: • Broad range. Well established: (1) Acute Lymphoblastic Leukemia of childhood. (2) Choriocarcinoma. (3) Cancers of breast, bladder, and head & neck. (4) Useful in non-Hodgkin's lymphomas