Phagocytes-Types of Cells Monocytes and macrophage Compared to neutrophils Arrive at damaged tissue later in infection Days after neutrophils have been active in fighting intruders Eventually settle in tissues and become resident macrophage BIOL 533 Lecture 6
BIOL 533 12 Lecture 6 Phagocytes—Types of Cells • Monocytes and macrophage – Compared to neutrophils • Arrive at damaged tissue later in infection – Days after neutrophils have been active in fighting intruders • Eventually settle in tissues and become resident macrophage
Phagocytes-Types of Cells Monocytes and macrophage Share progenitor cell type, but kinetics of maturation appearance are very different Monocytes continue cell differentiation after leaving bone marrow Monocytes and macrophage involved in both constitutive and inducible mechanisms Interact with T cells and play important role in cell mediated immunity BIOL 533 Lecture 6
BIOL 533 13 Lecture 6 Phagocytes—Types of Cells • Monocytes and macrophage – Share progenitor cell type, but kinetics of maturation & appearance are very different • Monocytes continue cell differentiation after leaving bone marrow • Monocytes and macrophage involved in both constititive and inducible mechanisms – Interact with T cells and play important role in cellmediated immunity
Phagocytes-Types of Cells Tissue(resident) macrophage Exist throughout body Different names and functions in different tissues Kupffer cells--liver Alveolar macrophage- lungs o Osteoclasts-bone ● Microglia- brain BIOL 533 Lecture 6
BIOL 533 14 Lecture 6 Phagocytes—Types of Cells • Tissue (resident) macrophage – Exist throughout body – Different names and functions in different tissues • Kupffer cells—liver • Alveolar macrophage—lungs • Osteoclasts—bone • Microglia—brain
Phagocytes-Types of Cells Monocyte and macrophage functions Phagocytize invading microbes Contribute greatly to inflammatory response e Releases IL-1-enhances sticking of neutrophil to capillary endothelia TNF-activates newly arrived neutrophils BIOL 533 Lecture 6
BIOL 533 15 Lecture 6 Phagocytes—Types of Cells • Monocyte and macrophage functions – Phagocytize invading microbes – Contribute greatly to inflammatory response • Releases – IL-1—enhances sticking of neutrophil to capillary endothelia – TNF—activates newly arrived neutrophils
E Mechanism of Phagocyte Killing Neutrophils General steps ● Attach to microbes Ingest microbes o Kill microbes Granules-considered as enlarged lysosomes containing hydrolytic enzymes BIOL 533 Lecture 6
BIOL 533 16 Lecture 6 Mechanism of Phagocyte Killing • Neutrophils – General steps • Attach to microbes • Ingest microbes • Kill microbes – Granules—considered as enlarged lysosomes containing hydrolytic enzymes