Phagocytes-Types of Cells Neutrophils--cell origin Actively motile cells produced in bone marrow Differentiate from stem cells over about a two-Week period Production of granules during this time Azurophil Produce specific granules later BIOL 533 7 Lecture 6
BIOL 533 7 Lecture 6 Phagocytes—Types of Cells • Neutrophils—cell origin – Actively motile cells produced in bone marrow – Differentiate from stem cells over about a two-week period • Production of granules during this time – Azurophil – Produce specific granules later
Phagocytes-Types of Cells Neutrophils--cell origin, continued Upon maturation(in numbers of 1010 per day, they move into peripheral blood and circulate for about 6.5 hours Next move into capillary bed and marginate BIOL 533 Lecture 6
BIOL 533 8 Lecture 6 Phagocytes—Types of Cells • Neutrophils—cell origin, continued – Upon maturation (in numbers of 1010 per day), they move into peripheral blood and circulate for about 6.5 hours – Next move into capillary bed and marginate
Phagocytes-Types of Cells Neutrophils--cell origin, continued Margination caused by stickiness due to interleukin-1 Summoned by chemotaxis, they move through endothelial cell junctions(diapdesis) into extravascular tissue spaces BIOL 533 Lecture 6
BIOL 533 9 Lecture 6 Phagocytes—Types of Cells • Neutrophils—cell origin, continued – Margination caused by stickiness due to interleukin-1 – Summoned by chemotaxis, they move through endothelial cell junctions (diapdesis) into extravascular tissue spaces
Phagocytes-Types of Cells Neutrophils are most active in gut Gut has enormous microbial population lying just one cell layer away from aseptic tissue Flora generates large amounts of chemotaxins that recruit most of body s available leukocytes BIOL 533 Lecture 6
BIOL 533 10 Lecture 6 Phagocytes—Types of Cells • Neutrophils are most active in gut – Gut has enormous microbial population lying just one cell layer away from aseptic tissue • Flora generates large amounts of chemotaxins that recruit most of body’s available leukocytes
Phagocytes-Types of Cells As a result submucosa of gut is in a constant state of inflammation Keep microbial flora down Synthesis of neutrophils inhibited by chemicals or radiation Infections in gut region BIOL 533 11 Lecture 6
BIOL 533 11 Lecture 6 Phagocytes—Types of Cells – As a result, submucosa of gut is in a constant state of inflammation • Keep microbial flora down – Synthesis of neutrophils inhibited by chemicals or radiation • Infections in gut region