氢氧化铝Aluminium hydroxide 校游 This compound is used as an antacid.The hydroxide reacts with excess acid in the stomach,reducing its acidity.This decrease of acidity of the contents of the stomach may in turn help to relieve the symptoms of ulcers,heartburn or dyspepsia.It can also cause constipation and is therefore often used with magnesium hydroxide or magnesium carbonate,which have counterbalancing laxative effects.It is also used to control phosphate(phosphorus)levels in the blood of people suffering from kidney failure. Cytoprotective Drugs 粘膜保护药 6
6 氢氧化铝 Aluminium hydroxide This compound is used as an antacid. The hydroxide reacts with excess acid in the stomach, reducing its acidity. This decrease of acidity of the contents of the stomach may in turn help to relieve the symptoms of ulcers, heartburn or dyspepsia. It can also cause constipation and is therefore often used with magnesium hydroxide or magnesium carbonate, which have counterbalancing laxative effects. It is also used to control phosphate (phosphorus) levels in the blood of people suffering from kidney failure. Cytoprotective Drugs 粘膜保护药
Blood Epithelialcell上皮细胞 Gastric lumen Sucralfate Cytoprotective effect Mucus- Mucus 粘膜保护 Bicarbonate- Bicarbonate PG( Misoprostol Parietal cell壁细胞 ⊙ -Protein kinases Histamine ④ H Cimetidine, famotidine. Lansoprazole and omeprazole ATPas Aluminum and and ranitidine magnesium hydroxides and calcium Acetylcholine carbonate Gastrin G 米索前列醇Misoprostol Agonist for the EP3 receptor Misoprostol is a drug that is used for the prevention of non steroidal anti inflammatory drug(NSAID)induced gastric ulcers.It acts upon gastric parietal cells,inhibiting the secretion of gastric acid via G-protein coupled receptor mediated inhibition of adenylate cyclase,which leads to decreased intracellular cAMP levels and decreased proton pump activity at the apical surface of the parietal cell. Misoprostol also promotes mucus and bicarbonate secretion from epithelial cells,which protects gastric lumen surface. 7
7 粘膜保护 壁细胞 上皮细胞 米索前列醇 Misoprostol Misoprostol is a drug that is used for the prevention of non steroidal anti inflammatory drug (NSAID) induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid via G-protein coupled receptor mediated inhibition of adenylate cyclase, which leads to decreased intracellular cAMP levels and decreased proton pump activity at the apical surface of the parietal cell. Misoprostol also promotes mucus and bicarbonate secretion from epithelial cells, which protects gastric lumen surface. Agonist for the EP3 receptor