Chapter 6 Protein synthesis 清莘大当
Chapter 6 Protein synthesis
6.1 Introduction 6.2 The stages of protein synthesis 6.3 Initiation in bacteria needs 30S subunits and accessory factors 6.4 A special initiator tRNA starts the polypeptide chain 6.5 Initiation involves base pairing between mRNA and rRNA 6.6 Small subunits scan for initiation sites on eukaryotic mRNA 6.7 Eukaryotes use a complex of many initiation factors 6.8 Elongation factor T loads aminoacyl-tRNA into the A site 6.9 Translocation moves the ribosome 6.10 Three codons terminate protein synthesis 6.11 Ribosomes have several active centers 6.12 The organization of 16S rRNA 6.13 23S rRNA has peptidyl transferase activity 清苇大兰
6.1 Introduction 6.2 The stages of protein synthesis 6.3 Initiation in bacteria needs 30S subunits and accessory factors 6.4 A special initiator tRNA starts the polypeptide chain 6.5 Initiation involves base pairing between mRNA and rRNA 6.6 Small subunits scan for initiation sites on eukaryotic mRNA 6.7 Eukaryotes use a complex of many initiation factors 6.8 Elongation factor T loads aminoacyl-tRNA into the A site 6.9 Translocation moves the ribosome 6.10 Three codons terminate protein synthesis 6.11 Ribosomes have several active centers 6.12 The organization of 16S rRNA 6.13 23S rRNA has peptidyl transferase activity
6.1 Ribosomes rRNAS Proteins Introduction Bacterial 505 238=2904 bases 31 Figure 6.1 70S 5S=120 bases Ribosomes are large mass:2.5 MDa 66%RNA ribonucleoprotein 309 168=1542 bases 21 particles that contain Mammalian more RNA than 288=4718 bases 60S 5.8S 160 bases protein and 80S 5S =120 bases 49 mass:4.2 MDa dissociate into large 60%RNA and small subunits 409 188=1874 bases 33 清菜大当
Figure 6.1 Ribosomes are large ribonucleoprotein particles that contain more RNA than protein and dissociate into large and small subunits. 6.1 Introduction
30S 6.1 Introduction 509 Figure 6.2 Electron microscopic images of bacterial ribosomes and subunits reveal their shapes.Photographs 70S kindly provided by James Lake. 清苇大当
Figure 6.2 Electron microscopic images of bacterial ribosomes and subunits reveal their shapes. Photographs kindly provided by James Lake. 6.1 Introduction
6.2 The stages of protein synthesis Figure 6.3 Size comparisons 200A show that the ribosome is large 60A enough to bind tRNAs and 220A mRNA. 35 base mRNA 情華大当
Figure 6.3 Size comparisons show that the ribosome is large enough to bind tRNAs and mRNA. 6.2 The stages of protein synthesis